66640-65-1

Basic information

• Product Name: Benzene, 2,5-dichloro-1-iodo-3-(methylsulfonyl)-
• CAS NO: 66640-65-1
• Molecular Formula: C7H5Cl2IO2S
• Molecular Weight: 350.992
• Mol File: 66640-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzene, 2,5-dichloro-1-iodo-3-(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2,5-dichloro-1-iodo-3-(methylsulfonyl)-(66640-65-1)
• EPA Substance Registry System: Benzene, 2,5-dichloro-1-iodo-3-(methylsulfonyl)-(66640-65-1)

Safety Data

• Hazardous Substances Data: 66640-65-1(Hazardous Substances Data)

Upstream product

• 66640-63-9 2,5-dichlorophenyl methyl sulfone 
• 5858-18-4 2,5-dichlorbenzenethiol 
• 66640-64-0 2,5-dichloro-3-nitrophenylmethylsulfone 

Relevant articles and documents

An alternative synthesis of chlorinated biphenyl methylsulfonyl metabolites

Published methods of synthesizing chlorinated biphenyl methylsulfones require the separation of a complex mixture of impurities and isomers using both normal and reverse phase HPLC. Even with semi-preparative scale equipment, the process is tedious and time-consuming. In this report, the palladium-catalyzed addition of an aryl iodide to an aryl trimethylstannane has been exploited to produce these compounds in high purity (≥ 99%) using conventional techniques of purification. The reaction has been demonstrated for a group of methylsulfonyl CBs representing 0 to 3 ortho-chlorine interactions between the biphenyl rings and with the methylsulfonyl group at either the 3- or 4- position.