66641-26-7 Usage
Biological Activity
acetyl angiotensinogen (1-14),porcine, (c87h125n21o21) is a peptide with the sequence ac-asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser-oh, mw= 1801.05. the protein encoded by the angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure(1). the resulting product, angiotensin i, is then cleaved by angiotensin converting enzyme (ace) to generate the physiologically active enzyme angiotensin ii. angiotensin ii is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia(2). mutations in the gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. defects in the gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.figure1 formula of acetyl angiotensinogen (1-14),porcinefigure2 the renin–angiotensin–aldosterone system
references
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.
Check Digit Verification of cas no
The CAS Registry Mumber 66641-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,4 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 66641-26:
(7*6)+(6*6)+(5*6)+(4*4)+(3*1)+(2*2)+(1*6)=137
137 % 10 = 7
So 66641-26-7 is a valid CAS Registry Number.
