66644-22-2

Basic information

• Product Name: ethyl (3-phenoxyphenyl)acetate
• Synonyms: ethyl (3-phenoxyphenyl)acetate
• CAS NO: 66644-22-2
• Molecular Weight: 256.301
• Mol File: 66644-22-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (3-phenoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (3-phenoxyphenyl)acetate(66644-22-2)
• EPA Substance Registry System: ethyl (3-phenoxyphenyl)acetate(66644-22-2)

Safety Data

• Hazardous Substances Data: 66644-22-2(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 64744-52-1 1-((E)-2-Methanesulfinyl-2-methylsulfanyl-vinyl)-3-phenoxy-benzene 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 591-50-4 iodobenzene 
• 22446-38-4 ethyl 3-hydroxyphenylacetate 
• 32852-81-6 (3-phenoxyphenyl)acetic acid 

Downstream Products

• 1357293-72-1 N-(3-nitrophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-73-2 N-(4-nitrophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-74-3 N-(naphthalen-1-yl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-75-4 N-benzhydryl-2-(3-phenoxyphenyl)acetamide 
• 1357293-76-5 N-(6-methoxybenzo[d]thiazol-2-yl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-77-6 N-(5-methylpyridin-2-yl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-78-7 2-(3-phenoxyphenyl)-N-(thiazol-2-yl)acetamide 
• 1357293-63-0 N-(3-chlorophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-64-1 N-(4-bromophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-65-2 N-(3,4-dichlorophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-66-3 N-(3,4-difluorophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-67-4 N-(4-bromo-2-chlorophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-68-5 N-(2-cyanophenyl)-2-(3-phenoxyphenyl)acetamide 
• 1357293-69-6 2-(3-phenoxyphenyl)-N-(4-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents

A series of compounds with a diphenyl ether nucleus were synthesized by incorporating various amines into the diphenyl ether scaffold with an amide bond. Their antitubercular activities were evaluated against Mycobacterium tuberculosis H37Rv by a microdilution method, with MIC values ranging from 4 to 64 μg/mL. Through structure-activity relationship studies, the two chlorine atoms at 3 and 4 positions in the phenyl ring of R2 group were found to play a significant role in the antitubercular activity. The most potent compound 6c showed an MIC value of 4 μg/mL and a good safety profile in HepG2 cell line by the MTT assay. Compound 6c was further found to be effective in a murine model of BCG infection, providing a good lead for subsequent optimization.