6665-16-3

Basic information

• Product Name: SER-LEU
• Synonyms: SER-LEU CRYSTALLINE
• CAS NO: 6665-16-3
• Molecular Formula: C₉H₁₈N₂O₄
• Molecular Weight: 218.251
• Mol File: 6665-16-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 222-228 °C
• Boiling Point: 465.8°Cat760mmHg
• Flash Point: 235.5°C
• Appearance: /
• Density: 1.256g/cm³
• PKA: 3.05±0.10(Predicted)
• CAS DataBase Reference: SER-LEU(CAS DataBase Reference)
• NIST Chemistry Reference: SER-LEU(6665-16-3)
• EPA Substance Registry System: SER-LEU(6665-16-3)

Safety Data

• Hazardous Substances Data: 6665-16-3(Hazardous Substances Data)

Usage

General Description

SER-LEU is a dipeptide composed of the amino acids serine (SER) and leucine (LEU). Serine is a nonessential amino acid that plays a crucial role in the synthesis of proteins and the production of several important molecules in the body. It is also a precursor to the neurotransmitter serotonin and is involved in the function of the immune system. Leucine is an essential amino acid that is important for protein synthesis and muscle growth. It also plays a role in regulating blood sugar levels and supporting the healing of skin and bones. Together, SER-LEU may have potential benefits for protein synthesis, muscle growth, and overall health.

Upstream product

• 65519-48-4 3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine 
• 6209-12-7 N-leucyl-serine 
• 2767-17-1 N-(N-benzyloxycarbonyl-L-seryl)-L-leucine benzyl ester 
• 115220-80-9 Boc-Ser(OtBu)-Leu-OEt 
• 2768-55-0 N-Benzyloxycarbonyl-L-seryl-L-leucin 
• 61-90-5 L-leucine 
• 2743-40-0 L-leucine ethyl ester hydrochloride 

Downstream Products

• 700372-65-2 Z-Val-Ser-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate] 

Relevant articles and documents

Structure determination of lepidopteran c, self-defence substance produced by silkworm (bombyx mori)

Lepidopteran C is a minor component in a group of lepidopterans which are self-defence substances produced in haemolymph of silkworm. Its structure was determined by the Edman degradation of the whole molecule as well as the fragments obtained by digestion of Staphylococcus aureus V8 protease, proline specific endopeptidase, and trypsin. Although lepidopteran C is similar to A in amino acid sequence, 11 amino acids of A are substituted in the sequence of C.

Proteasome inhibitors: Synthesis and activity of arecoline oxide tripeptide derivatives

We describe the synthesis and biological activities of a series of methyl 3,4-epoxypiperidine-3-carboxylate tripeptide derivatives that inhibit the chymotryptic and tryptic active sites of the 20S proteasome. Of the series, compound 2 which contains 3-hydroxy-2-methylbenzoyl group at its N-terminal position, displayed the greatest inhibitory potency (IC50 1 μM). All derivatives showed favourable pharmacokinetic properties.