666724-77-2Relevant articles and documents
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers
Zhu, Gui-Dong,Gandhi, Viraj B.,Gong, Jianchun,Luo, Yan,Liu, Xuesong,Shi, Yan,Guan, Ran,Magnone, Shayna R.,Klinghofer, Vered,Johnson, Eric F.,Bouska, Jennifer,Shoemaker, Alexander,Oleksijew, Anatol,Jarvis, Ken,Park, Chang,Jong, Ron De,Oltersdorf, Tilman,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 3424 - 3429 (2006)
We describe a series of potent and selective oxindole-pyridine-based protein kinase B/Akt inhibitors. The most potent compound 11n in this series demonstrated an IC50 of 0.17 nM against Akt1 and more than 100-fold selectivity over other Akt iso