6668-56-0

Basic information

• Product Name: 4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE
• Synonyms: Benzenesulfonyl chloride, 4-fluoro-3-nitro-;5-(Chlorosulphonyl)-2-fluoronitrobenzene;4-Fluoro-3-nitrobenzenesulphonylchloride99%
• CAS NO: 6668-56-0
• Molecular Formula: C₆H₃ClFNO₄S
• Molecular Weight: 239.61
• Mol File: 6668-56-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.685g/cm³
• Vapor Pressure: 3.9E-05mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE(6668-56-0)
• EPA Substance Registry System: 4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE(6668-56-0)

Safety Data

• Hazardous Substances Data: 6668-56-0(Hazardous Substances Data)

Usage

Description

4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE is an organic compound characterized by its chemical structure that features a benzene ring with a fluorine atom at the 4-position, a nitro group at the 3-position, and a sulfonyl chloride group attached to the benzene ring. 4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE is known for its reactivity and is commonly utilized in the synthesis of various pharmaceuticals and chemical compounds.

Uses

Used in Pharmaceutical Industry:
4-FLUORO-3-NITROBENZENESULFONYL CHLORIDE is used as a key intermediate in the synthesis of potent Bcl-2/Bcl-xL inhibitors. These inhibitors are crucial in the development of anti-cancer drugs due to their ability to target and disrupt the function of Bcl-2 and Bcl-xL proteins, which are known to promote cell survival and contribute to tumor growth. The use of this compound in the preparation of these inhibitors is driven by its reactivity and the potential for strong in vivo antitumor activity.

InChI:InChI=1/C6H3ClFNO4S/c7-14(12,13)4-1-2-5(8)6(3-4)9(10)11/h1-3H

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 3888-84-4 4-fluoro-3-nitro-benzenesulfonic acid 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 306964-85-2 ethyl 1-[(4-fluoro-3-nitrophenyl)sulfonyl]-1H-pyrrole-2-carboxylate 
• 406233-31-6 4-fluoro-3-nitrobenzenesulfonamide 
• 406233-35-0 4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide 
• 872866-39-2 4-((S)-3-dimethylamino-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide 
• 406233-33-8 (R)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid 
• 872866-37-0 (S)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid 
• 872866-38-1 (S)-N,N-dimethyl-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyramide 
• 406233-34-9 (R)-N,N-dimethyl-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyramide 
• 406235-25-4 4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutylamino)-3-nitrobenzenesulfonamide 
• 406233-50-9 4-((R)-5-dimethylamino-1-phenylsulfanylmethylpentylamino)-3-nitrobenzenesulfonamide 
• 872866-36-9 (S)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid tert-butyl ester 
• 406233-32-7 (R)-3-(2-nitro-4-sulfamoylphenylamino)-4-phenylsulfanylbutyric acid tert-butyl ester 
• 406235-62-9 4-((S)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide 
• 872866-27-8 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide 

Relevant articles and documents

New insights into 4-anilinoquinazolines as inhibitors of cardiac troponin I-interacting kinase (TNNI3K)

We report the synthesis of several related 4-anilinoquinazolines as inhibitors of cardiac troponin I-interacting kinase (TNNi3K). These close structural analogs of 3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide (GSK11

Dihydropteridinone-sulfamide derivatives, pharmaceutically-acceptable salts of derivatives, preparation method of derivatives and application of derivatives and salts

The invention provides dihydropteridinone-sulfamide derivatives as well as a preparation method and application thereof aiming at problems in the prior art, and provides a novel choice for developmentof an antitumor drug for inhibiting a bromodomain (BRD4

Amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide

An amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide is disclosed. According to the method, 4-halogeno-benzenesulfonyl chloride which is used as a raw material undergoes nitration to prepare 3-nitro-4-halogeno-benzenesulfonyl chloride; and after aminolysis, 3-nitro-4-halogeno-benzenesulfonamide is prepared. By the synthesis method provided by the invention, the synthesis route by the adoption of chlorosulfonic acid is changed, and production safety is remarkably raised. The reaction condition is milder and is easy for production control. Thus, mass production of the compound is easier to implement and realize.