667-71-0 Usage
Description
(20S)-20-Amino-5α-pregnan-3β-ol is a naturally occurring steroid derivative and a neurosteroid with a molecular formula C21H37NO2. It is involved in various physiological processes in the body and is the 20S epimer of pregnanolone. As an agonist of the GABAA receptor, the main inhibitory neurotransmitter receptor in the brain, it has been studied for its potential therapeutic effects in conditions such as anxiety, depression, and epilepsy. Furthermore, it has been found to possess neuroprotective properties, making it a subject of interest in research on neurodegenerative diseases. Overall, (20S)-20-Amino-5α-pregnan-3β-ol is a biologically important compound with potential pharmacological applications.
Used in Pharmaceutical Industry:
(20S)-20-Amino-5α-pregnan-3β-ol is used as a therapeutic agent for the treatment of neurological and psychiatric disorders due to its agonistic effects on the GABAA receptor, which helps in reducing anxiety, depression, and epilepsy symptoms.
Used in Neurodegenerative Disease Research:
(20S)-20-Amino-5α-pregnan-3β-ol is used as a neuroprotective agent in research on neurodegenerative diseases, given its potential to protect neurons and slow down the progression of these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 667-71-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,6 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 667-71:
(5*6)+(4*6)+(3*7)+(2*7)+(1*1)=90
90 % 10 = 0
So 667-71-0 is a valid CAS Registry Number.
667-71-0Relevant articles and documents
Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica
Kawamoto, Souichi,Koyano, Takashi,Kowithayakorn, Thaworn,Fujimoto, Haruhiro,Okuyama, Emi,Hayashi, Masahiko,Komiyama, Kanki,Ishibashi, Masami
, p. 737 - 739 (2007/10/03)
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3β-hydroxy-5α-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.
