667-92-5

Basic information

• Product Name: 8-Dichloroacetyl-5-hydroxy-2,7-dimethyl-1,4-naphthoquinone
• Synonyms: 8-Dichloroacetyl-5-hydroxy-2,7-dimethyl-1,4-naphthoquinone;Mollisin
• CAS NO: 667-92-5
• Molecular Formula: C14H10Cl2O4
• Molecular Weight: 313.1328
• Mol File: 667-92-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 582.1°Cat760mmHg
• Flash Point: 305.8°C
• Appearance: /
• Density: 1.491g/cm³
• Vapor Pressure: 3.79E-14mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 8-Dichloroacetyl-5-hydroxy-2,7-dimethyl-1,4-naphthoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Dichloroacetyl-5-hydroxy-2,7-dimethyl-1,4-naphthoquinone(667-92-5)
• EPA Substance Registry System: 8-Dichloroacetyl-5-hydroxy-2,7-dimethyl-1,4-naphthoquinone(667-92-5)

Safety Data

• Hazardous Substances Data: 667-92-5(Hazardous Substances Data)

Usage

Usage

Antimalarial and antipneumocystic medication

Mechanism of Action

Disrupts the electron transport chain in the mitochondria of Plasmodium and Pneumocystis organisms

Applications

Used in combination with proguanil for malaria prevention and treatment
Stand-alone medication for prevention and treatment of Pneumocystis pneumonia in HIV/AIDS patients

Dosage Forms

Tablets
Suspension

Safety Profile

Generally well-tolerated
Few adverse effects

InChI:InChI=1/C14H10Cl2O4/c1-5-3-7(17)10-8(18)4-6(2)12(19)11(10)9(5)13(20)14(15)16/h3-4,14,17H,1-2H3

Upstream product

• 945-40-4 3,6-dimethylnaphthalene-1,8-diol 
• 896-82-2 8-(2,2-dichloroacetyl)-5-methoxy-2,7-dimethylnaphthalene-1,4-dione 

Relevant articles and documents

Total synthesis of the antifungal natural product mollisin

Mollisin, a bioactive polyketide secondary metabolite of the fungus Mollisia caesia, was synthesized in nine linear steps from commercially available 2,6-dimethyl-γ-pyrone. A key transformation in this first total synthesis of mollisin was the ipso substi