66724-23-0

Basic information

• Product Name: 4H-1-Benzothiopyran-4-one, 2-(4-chlorophenyl)-
• CAS NO: 66724-23-0
• Molecular Formula: C15H9ClOS
• Molecular Weight: 272.755
• Mol File: 66724-23-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzothiopyran-4-one, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzothiopyran-4-one, 2-(4-chlorophenyl)-(66724-23-0)
• EPA Substance Registry System: 4H-1-Benzothiopyran-4-one, 2-(4-chlorophenyl)-(66724-23-0)

Safety Data

• Hazardous Substances Data: 66724-23-0(Hazardous Substances Data)

Upstream product

• 64448-06-2 (N-phenyliminovinylidene)triphenylphosphorane 
• 145702-36-9 2-(4-Chloro-benzoylsulfanyl)-benzoic acid 
• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 
• 405271-44-5 C₂₀H₂₃ClO₃SSi 
• 790-41-0 4-chlorobenzoic anhydride 
• 1072-85-1 o-fluorobromobenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 192573-58-3 3-(4-chlorophenyl)-1-(2-chlorophenyl)propyn-1-one 
• 89-98-5 2-chloro-benzaldehyde 
• 108-86-1 bromobenzene 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 13939-06-5 molybdenum hexacarbonyl 
• 104-88-1 4-chlorobenzaldehyde 
• 6048-06-2 ethyl-p-chlorocinnamate 

Downstream Products

• 6586-36-3 2-(4-chlorophenyl)-2,3-dihydro-4H-1-benzopyran-4-one 
• 78317-71-2 2-(4-Chlorphenyl)-3,4-dihydro-2H-1-benzothiopyran 

Relevant articles and documents

Nickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- And 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes

A nickel-catalyzed one-pot carbonylation reaction of 2-bromobenzenesulfonyl chlorides with alkynes for the synthesis of thiochromenones has been established. Both terminal and internal alkynes were suitable substrates in this carbonylative transformation, and a broad range of 2-mono- and 2,3-disubstituted thiochromenone products were obtained in moderate to good yields with quite high functional group compatibility. Notably, this procedure presents the first example of nickel-catalyzed carbonylative synthesis of thiochromenones with 2-bromobenzenesulfonyl chlorides as a promising sulfur precursor.

Competitive cascade cyclization of 2′-tosyloxychalcones: An easy access to thioflavones and thioaurones

A new and efficient approach for the synthesis of thioflavones and thioaurones by competitive cascade cyclization of 2′-tosyloxychalcones has been developed. 2′-Tosyloxychalcones were smoothly converted into thioflavones and thioaurones by incorporation of sulfur atom using elemental sulfur and triethylamine in DMSO with good yields. The advantages of the methodology are the formation of both thioflavones and thioaurones in a single step. Easily accessible substrates, mild reaction conditions and compatibility with a broad range of functional groups make this protocol clean and inexpensive.

Carbonylative Synthesis of Thiochromenones via Palladium-Catalyzed tert -Butyl Isocyanide Insertion

A flexible and efficient carbonylative synthesis of thiochromenones from the commercially available materials by utilizing tert -butyl isocyanide as carbonyl source has been developed. This methodology efficiently constructs thiochromenones in moderate to excellent yields with the advantages of wide range of substrates and being applicable to library synthesis.