66730-28-7

Basic information

• Product Name: Benzamide, N-(1,2-diphenylethyl)-
• CAS NO: 66730-28-7
• Molecular Formula: C21H19NO
• Molecular Weight: 301.388
• Mol File: 66730-28-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(1,2-diphenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(1,2-diphenylethyl)-(66730-28-7)
• EPA Substance Registry System: Benzamide, N-(1,2-diphenylethyl)-(66730-28-7)

Safety Data

• Hazardous Substances Data: 66730-28-7(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 3082-58-4 (-)-1,2-diphenylethylamine 
• 98-88-4 benzoyl chloride 
• 1589-82-8 phenylmagnesium bromide 
• 1485-70-7 N-benzylbenzamide 
• 60000-09-1 1,2-diphenyl-1-ethylamine hydrochloride 
• 100-51-6 benzyl alcohol 
• 100-42-5 styrene 
• 100-47-0 benzonitrile 
• 100-44-7 benzyl chloride 
• 27962-33-0 N-(diphenylmethylidene)-1,2-diphenylethylamine 
• 77444-02-1 Methyl N-(2-chloro-1,2-diphenylethyl)carbamate 
• 102478-96-6 1,2-Diphenyl-2-benzoyloxyethylamine hydrochloride 
• 77444-03-2 Ethyl N-chloro-N-(2-chloro-1,2-diphenylethyl)carbamate 

Downstream Products

• 77988-83-1 N-(1,2-diphenylethyl)benzimidoyl chloride 
• 103-30-0 (E)-1,2-diphenyl-ethene 

Relevant articles and documents

Peroxidation of C-H bonds adjacent to an amide nitrogen atom under mild conditions

Under mild conditions, the oxidative functionalization of C-H bonds adjacent to an amide nitrogen atom was achieved. tert-Butylperoxyamido acetal was obtained in high yields and could be further converted into α-substituted amides by treatment with Grigna

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2$4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.

Carbon-carbon bond formations at the benzylic positions of N-benzylxanthone imines and N-benzyldi-1-naphthyl ketone imine

Two N-benzyl imines are designed to allow for carbon-carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi-1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide afford the corresponding 1-phenylalkylamines in high yields. Conjugate addition of N-benzyldi-1-naphthyl ketone imine is also described.