667403-46-5Relevant articles and documents
p53 DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION
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Paragraph 0088; 0090; 0094; 0096, (2019/10/10)
A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.
PROCESS FOR MAKING IXAZOMIB OR INTERMEDIATES THEREFOR
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, (2019/03/12)
This invention relates to a process for preparing Ixazomib 1, its trimer 1.trimer, its citrate ester 2 or an intermediate for their synthesis. The process comprising at least one amide coupling reaction in the presence of a cyclic alkyl triphosphonic anhy
Synthetic process research of ixazomib
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, (2019/11/04)
The invention discloses a synthesis method of ixazomib. The yield and the purity of a target product can be greatly increased with the method.