6678-82-6 Usage
Description
1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINEHYDROCHLORIDE is a hydrochloride salt with a molecular formula of C13H15N, belonging to the beta-carboline family of chemical compounds. It is a heterocyclic amine, characterized by a ring structure that includes atoms of at least two different elements. 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINEHYDROCHLORIDE is known for its various biological activities and is often found in naturally occurring substances such as plants and fungi. Its potential pharmacological properties, including its role as a neurotransmitter modulator, make it a promising candidate for the development of new pharmaceuticals.
Uses
Used in Pharmaceutical Development:
1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINEHYDROCHLORIDE is used as a compound with potential pharmacological properties for the development of new pharmaceuticals. Its role as a neurotransmitter modulator makes it a valuable asset in the creation of medications targeting neurological conditions and disorders.
Used in Neurotransmitter Modulation Research:
In the field of neuroscience, 1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINEHYDROCHLORIDE is used as a research tool to study the modulation of neurotransmitters. Understanding its effects on neurotransmission can lead to advancements in the treatment of neurological disorders and the development of more effective therapies.
Used in Natural Substances Analysis:
1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINEHYDROCHLORIDE is used in the analysis of naturally occurring substances, such as plants and fungi, to identify and study the presence of beta-carboline compounds. This analysis can contribute to the discovery of new bioactive compounds with potential applications in medicine and pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 6678-82-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,7 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6678-82:
(6*6)+(5*6)+(4*7)+(3*8)+(2*8)+(1*2)=136
136 % 10 = 6
So 6678-82-6 is a valid CAS Registry Number.
6678-82-6Relevant articles and documents
Monoamine oxidase (MAO-N) catalyzed deracemization of tetrahydro-β- carbolines: Substrate dependent switch in enantioselectivity
Ghislieri, Diego,Houghton, Deborah,Green, Anthony P.,Willies, Simon C.,Turner, Nicholas J.
, p. 2869 - 2872 (2014/01/06)
The tetrahydro-β-carboline (THBC) ring system is an important structural motif found in a large number of bioactive alkaloid natural products. Herein we report a broadly applicable method for the synthesis of enantiomerically pure β-carbolines via a deracemization procedure employing the D9 and D11 variants of monoamine oxidase from Aspergillus niger (MAO-N) in combination with a nonselective chemical reducing agent. Biotransformations were performed on a preparative scale, leading to the synthesis of optically enriched products in excellent enantiomeric excess (e.e.; up to 99%) and isolated yield (up to 93%). Interestingly, a switch in enantioselectivity associated with the MAO-N variants is observed as the nature of the C-1 substituent of the THBC is varied. Molecular modeling provided an explanation for this observation and highlighted key active site residues which were modified, resulting in an increase in (R)-selectivity associated with the enzyme. These results provide insight into the factors which influence the selectivity of the MAO-N variants, and may offer a platform for future directed evolution projects aimed toward the challenge of engineering (R)-selective amine oxidase biocatalysts.