66789-03-5 Usage
Description
17BETA-ESTRADIOL-2,4,16,16-D4, also known as Estradiol-d4, is a synthetically produced isotope-labeled compound that serves as an internal standard for the quantification of Estradiol. It is a major estrogen secreted by the premenopausal ovary and is also listed as a drinking water contaminant candidate by the United States Environmental Protection Agency (EPA). 17BETA-ESTRADIOL-2,4,16,16-D4 is essential for accurate and reliable measurement of Estradiol levels in various applications.
Uses
Used in Mass Spectrometry Applications:
17BETA-ESTRADIOL-2,4,16,16-D4 is used as an internal standard for the quantification of Estradiol by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. It helps ensure accurate and reliable measurement of Estradiol levels in various samples, such as biological fluids, environmental samples, and food products.
Used in Environmental Analysis:
17BETA-ESTRADIOL-2,4,16,16-D4 is used as a reference compound in environmental analysis to monitor and control the presence of Estradiol in drinking water. As a contaminant candidate listed by the EPA, it plays a crucial role in ensuring the safety and quality of drinking water supplies.
Used in Pharmaceutical and Biomedical Research:
17BETA-ESTRADIOL-2,4,16,16-D4 is used as a research tool in pharmaceutical and biomedical studies to investigate the role of Estradiol in various physiological processes and diseases. Its stable isotope labeling allows for precise tracking and quantification of Estradiol in experimental settings, contributing to a better understanding of its functions and potential therapeutic applications.
Used in Food Contamination Analysis:
17BETA-ESTRADIOL-2,4,16,16-D4 is used in the analysis of food contaminants to ensure the safety and quality of food products. As a component of the EPA's drinking water contaminant candidate list, it helps monitor and control the presence of Estradiol in food items, protecting public health and maintaining food safety standards.
Check Digit Verification of cas no
The CAS Registry Mumber 66789-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,7,8 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66789-03:
(7*6)+(6*6)+(5*7)+(4*8)+(3*9)+(2*0)+(1*3)=175
175 % 10 = 5
So 66789-03-5 is a valid CAS Registry Number.
66789-03-5Relevant articles and documents
Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters
Kiuru, Paula S.,Waehaelae, Kristiina
, p. 54 - 60 (2007/10/03)
Deuterated analogs of estrogen fatty acid esters are needed as internal standards for isotope dilution GC/MS analyses. We have developed a rapid and efficient synthesis for 2,4,16,16-D4-estrone palmitate, stearate, oleate, linoleate, and linolenate and the corresponding 2,4,16,16,17α- D5-estradiol fatty acid 17-mono and 3,17-diesters using analogous fatty acid chlorides or fatty acid anhydrides and 4-(dimethylamino)pyridine under microwave irradiation. Chemoselective hydrolysis of fatty acid diesters was carried out by KOH in t-BuOH.
