6683-28-9

Basic information

• Product Name: methyl ((benzyloxy)carbonyl)-L-tryptophyl-L-phenylalaninate
• Synonyms: methyl ((benzyloxy)carbonyl)-L-tryptophyl-L-phenylalaninate
• CAS NO: 6683-28-9
• Molecular Weight: 499.566
• Mol File: 6683-28-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl ((benzyloxy)carbonyl)-L-tryptophyl-L-phenylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl ((benzyloxy)carbonyl)-L-tryptophyl-L-phenylalaninate(6683-28-9)
• EPA Substance Registry System: methyl ((benzyloxy)carbonyl)-L-tryptophyl-L-phenylalaninate(6683-28-9)

Safety Data

• Hazardous Substances Data: 6683-28-9(Hazardous Substances Data)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1152312-13-4 C₃₅H₃₃IN₄O₅ 
• 403655-43-6 Benzoic acid 3-((2S,5S)-5-benzyl-3,6-dioxo-piperazin-2-ylmethyl)-indol-1-yl ester 
• 180910-59-2 (3S,6S)-(-)-6-(1-hydroxyindol-3-ylmethyl)-3-benzyl-2,5-piperazinedione 
• 403655-36-7 (3S,6S)-3-Benzyl-6-(2,3-dihydro-1H-indol-3-ylmethyl)-piperazine-2,5-dione 
• 82597-82-8 cyclo(L-tryptophyl-L-phenylalanyl) 

Relevant articles and documents

Benzoisothiazolone organo/copper-cocatalyzed redox dehydrative construction of amides and peptides from carboxylic acids using (EtO)3P as the reductant and O2 in air as the terminal oxidant

Carboxylic acids and amine/amino acid reactants can be converted to amides and peptides at neutral pH within 5-36 h at 50 °C using catalytic quantities of a redox-active benzoisothiazolone and a copper complex. These catalytic "oxidation-reduction condensation" reactions are carried out open to dry air using O2 as the terminal oxidant and a slight excess of triethyl phosphite as the reductant. Triethyl phosphate is the easily removed byproduct. These simple-to-run catalytic reactions provide practical and economical procedures for the acylative construction of C-N bonds.

Simple synthesis of 1,3,4,5a,6,10b,11,11a-octahydro-2H-pyrazino[1′,2′:1,5]pyrrolo[2, 3-b]indole derivatives based on 1-hydroxyindole chemistry

3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazinediones are prepared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR,10bS,11as)-1,3,4,5a,6,10b,11, 11a-octahydro-2H-pyrazino[