66866-01-1

Basic information

• Product Name: 1H-Indole, 7-chloro-2-phenyl-
• CAS NO: 66866-01-1
• Molecular Formula: C14H10ClN
• Molecular Weight: 227.693
• Mol File: 66866-01-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 7-chloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 7-chloro-2-phenyl-(66866-01-1)
• EPA Substance Registry System: 1H-Indole, 7-chloro-2-phenyl-(66866-01-1)

Safety Data

• Hazardous Substances Data: 66866-01-1(Hazardous Substances Data)

Usage

Chemical class

Indole derivatives

Explanation

1H-Indole, 7-chloro-2-phenylis a compound that belongs to the class of indole derivatives, which are heterocyclic organic compounds.

Explanation

It consists of a carbon-nitrogen ring structure, which is characteristic of heterocyclic organic compounds.

Explanation

The indole ring has a chloro (-Cl) group at position 7 and a phenyl (-C6H5) group at position 2.

Explanation

1H-Indole, 7-chloro-2-phenylhas been studied for its potential pharmacological properties, including its ability to inhibit the growth of microorganisms and its potential to combat cancer cells.

Explanation

This compound serves as a starting material or building block in the synthesis of various other biologically active compounds and pharmaceuticals, making it valuable in the field of medicinal chemistry.

Explanation

1H-Indole, 7-chloro-2-phenylhas been found to exhibit unique and interesting properties in chemical and material science research, making it a versatile molecule in these fields of study.

Structure

Heterocyclic organic compound

Substituents

Chloro and phenyl groups

Pharmacological properties

Antimicrobial and anticancer activities

Synthesis building block

Used in the synthesis of biologically active compounds and pharmaceuticals

Chemical and material science research

Exhibits interesting properties

Upstream product

• 615-41-8 2-iodochlorobenzene 
• 7654-06-0 3-phenyl-2H-azirine 
• 1449517-00-3 C₁₅H₁₀BrClN₂ 
• 100948-87-6 1-(2-chlorophenyl)-1H-1,2,3,4-tetrazole 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 19433-17-1 (E)‐1‐phenylethan‐1‐one O‐acetyl oxime 
• 613-91-2 acetophenone oxime 
• 19433-17-1 acetophenone O-acetyloxime 
• 100-47-0 benzonitrile 
• 85089-31-2 3-chloro-2-fluorotoluene 
• 95-51-2 o-chloroaniline 
• 53924-05-3 7-chloro-1H-indole 
• 613-94-5 benzoic acid hydrazide 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 1060749-18-9 (7-chloro-2-phenylindol-3-yl)glyoxylyl chloride 
• 1025807-12-8 4-(7-chloro-2-phenyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 94303-62-5 7-chloro-3-morpholin-4-ylmethyl-2-phenyl-indole 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

Synthetic method of 2-substituted indoles compounds

The invention discloses a synthetic method of 2-substituted indoles compounds, and belongs to the organic synthesis field. 2-fluorotoluene compound shown in formula 1 and nitrile compound shown in formula 2 mix with an organic solvent in the presence of strong alkali and cesium salt additives, and react to synthesize the 2-substituted indoles compounds shown in formula 3. The synthesis method of 2-substituted indoles compounds is simple, economical and has wider applicability, is suitable for large-scale production, and has a very important influence on the synthesis of indoles compounds.

Indole-3-carbonitriles as DYRK1A inhibitors by fragment-based drug design

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer's disease. The selective DYRK1A inhibitor 10-iodo-11H-indolo[3, 2-c]quinoline-6-carboxy