66866-07-7

Basic information

• Product Name: 5-CHLORO-2-P-TOLYL-1H-INDOLE
• Synonyms: 5-CHLORO-2-P-TOLYL-1H-INDOLE
• CAS NO: 66866-07-7
• Molecular Formula: C₁₅H₁₂ClN
• Molecular Weight: 241.71548
• Mol File: 66866-07-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-CHLORO-2-P-TOLYL-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-P-TOLYL-1H-INDOLE(66866-07-7)
• EPA Substance Registry System: 5-CHLORO-2-P-TOLYL-1H-INDOLE(66866-07-7)

Safety Data

• Hazardous Substances Data: 66866-07-7(Hazardous Substances Data)

Usage

Description

5-CHLORO-2-P-TOLYL-1H-INDOLE is a chemical compound that belongs to the class of indole derivatives. It is characterized by the presence of a chlorine atom at the 5th position and a p-tolyl group at the 2nd position on the indole ring. This chemical may be used in various organic synthesis reactions and has potential pharmacological properties. It is often studied for its potential use in the development of pharmaceuticals and is of interest to chemists and researchers working in the field of organic chemistry and drug discovery.

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and potential pharmacological properties make it a valuable compound for the development of new drugs.
Used in Organic Synthesis:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a key building block in the synthesis of complex organic molecules. Its reactivity and functional groups allow for various chemical reactions, making it a versatile compound in organic chemistry.
Used in Drug Discovery Research:
5-CHLORO-2-P-TOLYL-1H-INDOLE is used as a research tool in drug discovery. Its potential pharmacological properties and unique structure make it an interesting candidate for the development of new therapeutic agents. Researchers in the field of drug discovery use this compound to study its interactions with biological targets and evaluate its potential as a lead compound for further development.

Upstream product

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Relevant articles and documents

Regioselective Synthesis of 2-Arylindoles via Palladium-Catalyzed Cyclization of Phenylglyoxal and 2-Anilinoacetophenones with Anilines

A versatile route has been developed for the synthesis of 2-arylindoles using a Pd-catalyzed tandem process. Under reductive conditions, different 2-arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2-anilinoacetophenones intermediates also can be using to give access to the corresponding 2-arylindoles.

Design and applications of new phosphine-free tetradentate Pd-catalyst: Regioselective C–H activation on 1-substituted 1,2,3-triazoles and indoles(NH-Free)

This article describes the synthesis of a new phosphine free tetradentate Pd catalyst using dl-2,3-diaminopropionic acid. The complex was characterized by Mass, IR, and 1H NMR. The catalyst is air stable at room temperature and non-hygroscopic. Application of this new catalyst to regioselective C–H activation on 1-substituted 1,2,3-triazole and indoles with aryl iodides to get corresponding C-5 and C-2 arylated products with satisfactory yields. All the products were characterized by spectroscopic studies.

Indium-HI-mediated one-pot reaction of 1-(2-arylethynyl)-2-nitroarenes to 2-arylindoles

While 1-(2-arylethynyl)-2-nitroarenes were reduced to 2-(2-arylethynyl)anilines in the presence of indium and InCl3 in THF/H2O (v/v = 5/1) at 50 °C, 1-(2-arylethynyl)-2-nitroarenes were reductively cyclized to 2-arylindoles with good yields in the presence of indium and aqueous HI in benzene.