668981-01-9

Basic information

• Product Name: α-Tosyl-(2,5-difluorobenzyl)isocyanide
• Synonyms: α-Tosyl-(2,5-difluorobenzyl)isocyanide;a-Tosyl-(2,5-difluorobenzyl)isocyanide;1,4-Difluoro-2-(isocyano(tosyl)methyl)benzene;Benzene,1,4-difluoro-2-[isocyano[(4-methylphenyl)sulfonyl]methyl]-
• CAS NO: 668981-01-9
• Molecular Formula: C₁₅H₁₁F₂NO₂S
• Molecular Weight: 307.319
• EINECS: 604-604-1
• Mol File: 668981-01-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Tosyl-(2,5-difluorobenzyl)isocyanide(CAS DataBase Reference)
• NIST Chemistry Reference: α-Tosyl-(2,5-difluorobenzyl)isocyanide(668981-01-9)
• EPA Substance Registry System: α-Tosyl-(2,5-difluorobenzyl)isocyanide(668981-01-9)

Safety Data

• Hazardous Substances Data: 668981-01-9(Hazardous Substances Data)

Usage

General Description

α-Tosyl-(2,5-difluorobenzyl)isocyanide is a chemical compound with the molecular formula C16H12F2NO2S. It is a highly reactive organic compound used in various chemical reactions, particularly in the synthesis of pharmaceuticals and agrochemicals. The compound contains a tosyl group and a difluorobenzyl group, both of which contribute to its reactivity and chemical properties. α-Tosyl-(2,5-difluorobenzyl)isocyanide is known for its strong odor and should be handled with caution due to its potential irritant and toxic effects. Despite its reactivity and potential hazards, this compound plays a crucial role in organic synthesis and is an important building block for many complex molecules used in the pharmaceutical industry.

Upstream product

• 668981-00-8 N-[(2,5-DIFLUORO-PHENYL)-(TOLUENE-4-SULFONYL)-METHYL]-FORMAMIDE 

Relevant articles and documents

Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines

The present invention relates to novel cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

NOVEL PROCESSES AND INTERMEDIATES FOR PREPARING TRIAZOLO-PYRIDINES

The present invention relates and intermediates to a novel process for preparing triazolo-pyridines of the formula I wherein R1 is selected from the group consisting of hydrogen, (C,-C6)alkyl or other suitable substituents; R3 is selected from the group consisting óf hydrogen, (Cl-C6)alkyl or other suitable substituents; s is an integer from 0-5; R4is hydrogen or a suitable substituent and to intermediates for their preparation. The compounds prepared by the methods of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

Alkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines

The present invention relates to novel alkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.