66899-02-3 Usage
Description
4,4-Dimethyl-2-pyrrolidinone, also known as DMP, is an organic compound with the chemical formula C6H11NO. It is a colorless liquid with a low melting point and a low boiling point. DMP is a polar aprotic solvent that is widely used in various industries due to its unique properties, such as high solubility, low toxicity, and good stability.
Uses
Used in Pharmaceutical Industry:
4,4-Dimethyl-2-pyrrolidinone is used as a pharmaceutical intermediate for the synthesis of various drugs, including benzoylthiophenes, which are allosteric enhancers of agonist activity at the A1 adenosine receptor. This application takes advantage of DMP's solubility and reactivity in facilitating chemical reactions.
Used in Chemical Synthesis:
In the chemical synthesis industry, 4,4-dimethyl-2-pyrrolidinone is used as a solvent for various organic reactions, such as esterification, transesterification, and hydrogenation. Its polar aprotic nature makes it an ideal choice for reactions involving sensitive functional groups, as it does not participate in unwanted side reactions.
Used in Polymer Industry:
4,4-Dimethyl-2-pyrrolidinone is used as a solvent in the polymer industry for the production of polyurethanes, polyamides, and other polymers. Its ability to dissolve a wide range of polymers makes it a versatile choice for various applications, such as coatings, adhesives, and elastomers.
Used in Battery Industry:
In the battery industry, 4,4-dimethyl-2-pyrrolidinone is used as an electrolyte solvent in lithium-ion batteries. Its high dielectric constant and low viscosity contribute to improved battery performance and energy density.
Used in Extraction Processes:
4,4-Dimethyl-2-pyrrolidinone is used in extraction processes to separate various compounds, such as metal ions, organic acids, and pharmaceuticals, from complex mixtures. Its high solubility and selectivity make it an effective choice for purification and separation applications.
Check Digit Verification of cas no
The CAS Registry Mumber 66899-02-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,8,9 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66899-02:
(7*6)+(6*6)+(5*8)+(4*9)+(3*9)+(2*0)+(1*2)=183
183 % 10 = 3
So 66899-02-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO/c1-6(2)3-5(8)7-4-6/h3-4H2,1-2H3,(H,7,8)
66899-02-3Relevant articles and documents
Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof
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Paragraph 0603; 0606; 0615-0616, (2021/07/28)
The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.
Structural insight into hybrid peptide ?-helices
Misra, Rajkumar,George, Gijo,Reja, Rahi M.,Dey, Sanjit,Raghothama, Srinivasarao,Gopi, Hosahudya N.
, p. 2171 - 2173 (2020/02/27)
Unique ?-helical organizations (11-helices) from β,γ-hybrid peptides composed of chiral β3-amino acids along with achiral 3,3- or 4,4-dimethyl substituted γ-amino acids are disclosed.
Selective formation of γ-lactams via C-H amidation enabled by tailored iridium catalysts
Hong, Seung Youn,Park, Yoonsu,Hwang, Yeongyu,Kim, Yeong Bum,Baik, Mu-Hyun,Chang, Sukbok
, p. 1016 - 1021 (2018/03/09)
Intramolecular insertion of met al nitrenes into carbon-hydrogen bonds to form γ-lactam rings has traditionally been hindered by competing isocyanate formation. We report the application of theory and mechanism studies to optimize a class of pentamethylcyclopentadienyl iridium(III) catalysts for suppression of this competing pathway. Modulation of the stereoelectronic properties of the auxiliary bidentate ligands to be more electron-donating was suggested by density functional theory calculations to lower the C-H insertion barrier favoring the desired reaction. These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding γ-lactams via sp3 and sp2 C-H amidation with exceptional selectivity. The power of this method was further demonstrated by the successful late-stage functionalization of amino acid derivatives and other bioactive molecules.
