66900-32-1 Usage
Description
(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl (4xi)-2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-threo-hexopyranoside is a complex tetracycline antibiotic derived from the bacterium Streptomyces spheroides. It is a semi-synthetic derivative of tetracycline, featuring a tetracycline core with additional functional groups and amino sugars, which contribute to its broad-spectrum antibacterial activity.
Uses
Used in Pharmaceutical Industry:
(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl (4xi)-2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-threo-hexopyranoside is used as an antibiotic for the treatment of various bacterial infections. Its unique chemical structure allows it to inhibit bacterial growth effectively, making it a valuable asset in combating resistant strains and treating a wide range of infections.
Check Digit Verification of cas no
The CAS Registry Mumber 66900-32-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,0 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66900-32:
(7*6)+(6*6)+(5*9)+(4*0)+(3*0)+(2*3)+(1*2)=131
131 % 10 = 1
So 66900-32-1 is a valid CAS Registry Number.
66900-32-1Relevant articles and documents
Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion
Masquelier,Baurain,Trouet
, p. 1166 - 1170 (2007/10/02)
The synthesis of amino acid and dipeptide derivatives of daunorubicin (DNR) is described. The binding-affinity parameters for DNA of those derivatives were determined by a spectral titration method. The affinity constants of the amino acid and dipeptide derivatives are, respectively, three and ten times lower than that of DNR. The susceptibility of those derivatives toward lysosomal peptidases was studied. It was found that the Leu and the Ala-Leu derivatives are the most rapidly hydrolyzed into DNR. It is concluded that Leu-DNR and Ala-Leu-DNR could act as prodrugs of DNR, which could be activated inside or in the close vicinity of tumor cells which display a high aminopeptidase activity.
