669066-90-4 Usage
Description
5-Bromo-3-fluoropicolinaMide is an organic compound that serves as a crucial building block in the synthesis of Favipiravir (F103350), an antiviral medication. It is characterized by its bromine and fluorine substitutions on the picolinamide structure, which contribute to its biological activity and potential applications in the pharmaceutical industry.
Uses
Used in Antiviral Applications:
5-Bromo-3-fluoropicolinaMide is used as a building block for the synthesis of Favipiravir, an antiviral agent. Favipiravir is particularly effective in the treatment of advanced Ebola virus infection in small animal models. It has been shown to suppress the replication of Zaire Ebola virus and prevent lethal outcomes in 100% of the animals treated. Based on these studies, Favipiravir, and by extension, 5-Bromo-3-fluoropicolinaMide, can be considered a promising candidate for the treatment of Ebola hemorrhagic fever.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-3-fluoropicolinaMide is used as a key intermediate in the development of new antiviral drugs. Its unique structural features make it a valuable component in the design and synthesis of novel therapeutic agents targeting various viral infections. 5-broMo-3-fluoropicolinaMide's role in the synthesis of Favipiravir highlights its potential for further research and development in the fight against viral diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 669066-90-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,9,0,6 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 669066-90:
(8*6)+(7*6)+(6*9)+(5*0)+(4*6)+(3*6)+(2*9)+(1*0)=204
204 % 10 = 4
So 669066-90-4 is a valid CAS Registry Number.
InChI:InChI=1S/C6H4BrFN2O/c7-3-1-4(8)5(6(9)11)10-2-3/h1-2H,(H2,9,11)
669066-90-4Relevant articles and documents
Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series
Kuduk, Scott D.,DiPardo, Robert M.,Chang, Ronald K.,Di Marco, Christina N.,Murphy, Kathy L.,Ransom, Richard W.,Reiss, Duane R.,Tang, Cuyue,Prueksaritanont, Thomayant,Pettibone, Douglas J.,Bock, Mark G.
, p. 3608 - 3612 (2008/02/08)
SAR study of the biphenyl region of cyclopropanecarboxamide derived bradykinin B1 antagonists was examined. Incorporation of a pyridine in place of the proximal phenyl ring and chlorination of the distal phenyl ring proved to be well tolerated
ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS
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Page/Page column 25, (2008/06/13)
α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3)(CH2)nNRbSO2Rd.(4)(CH2)nNRbCO2Ra.(5)(CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or(b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6)(CH2)kCO2Ra.and (7)(CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3-to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl;
