66916-98-1

Basic information

• Product Name: 2-(2-bromo-4-methoxyphenyl)acetonitrile
• Synonyms: 2-(2-bromo-4-methoxyphenyl)acetonitrile
• CAS NO: 66916-98-1
• Molecular Weight: 226.073
• Mol File: 66916-98-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-4-methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-4-methoxyphenyl)acetonitrile(66916-98-1)
• EPA Substance Registry System: 2-(2-bromo-4-methoxyphenyl)acetonitrile(66916-98-1)

Safety Data

• Hazardous Substances Data: 66916-98-1(Hazardous Substances Data)

Usage

General Description

2-(2-bromo-4-methoxyphenyl)acetonitrile is a chemical compound with the formula C10H8BrNO. It is a nitrile derivative, meaning it contains a carbon triple-bonded to a nitrogen atom, and it also contains a bromine and a methoxy group attached to a phenyl ring. 2-(2-bromo-4-methoxyphenyl)acetonitrile is commonly used in organic synthesis as a building block for the development of various pharmaceuticals, agrochemicals, and fine chemicals. It is also used as an intermediate in the production of dyes and pigments. Its unique structure and properties make it a valuable component in the field of chemical research and development.

Upstream product

• 54788-18-0 2-bromo-1-(bromomethyl)-4-methoxybenzene 
• 333-20-0 potassium thioacyanate 
• 36942-56-0 3-bromo-4-methylanisole 
• 66916-97-0 2-bromo-4-methoxybenzyl chloride 
• 2398-37-0 3-methoxyphenyl bromide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1393491-76-3 2-(2-bromo-4-methoxyphenyl)-2-methylpropanenitrile 
• 111359-29-6 6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine 
• 1273547-10-6 (3S)-(E)-N-Boc-N-[2-[2-[3-hydroxybut-1-enyl]-4-methoxyphenyl]ethyl]amine 
• 1273547-01-5 (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)-but-1-enyl]-4-methoxyphenyl]ethyl]amine 
• 1273546-88-5 tert-butyl 2-bromo-4-methoxyphenethylcarbamate 
• 198630-98-7 Ethyl 3-[2-(2-bromo-4-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate 

Relevant articles and documents

Construction of 1,3-Dithio-Substituted Tetralins by [1,5]-Alkylthio Group Transfer Mediated Skeletal Rearrangement

A novel skeletal rearrangement involving a [1,5]-alkylthio group transfer/cyclization sequence is described. Treatment of benzylidene malonates having a thioketal moiety at the homobenzyl position with a catalytic amount of Sc(OTf)3 afforded alkylthio group rearranged adducts in good chemical yields. Detailed investigation of the reaction mechanism revealed that an intramolecular conjugate addition/ring opening sequence (not through-space transfer) is the key to achieving this reaction.

Gold-catalyzed 1,2-oxoarylations of nitriles with pyridine-derived oxides

We report the first success in the gold-catalyzed oxoarylations of nitriles with pyridine-derived N-oxides using gold carbenes as initiators. These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations, including diverse alkenyldiazo esters, nitriles, and pyridine-based oxides. Spill the (car)benes: Reported herein is the first successful gold-catalyzed oxoarylation of nitriles with pyridine-derived N-oxides using gold carbenes as initiators (see scheme; DCE=1,2-dichloroethane, IPr=1,3-bis(diisopropylphenyl)imidazol-2-ylidene). These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations using a variety of alkenyldiazo esters, nitriles, and pyridine-based N-oxides.

Regioselective aryl radical cyclisation. Part 2. Synthesis of octahydro-1H-dibenzo[a,d]cycloheptenes through 7-endo ring closure

A simple convergent synthesis of trans- and cis-octahydro-1H-dibenzo[a,d]cycloheptenes 15a-c and 16a-c and 20a-c and 21a-c through implementation of a regioselective 7-endo-trig-aryl radical cyclisation of the respective 2-(o-bromoarylethyl)-1-methylenecy