66934-10-9

Basic information

• Product Name: Benzamide, N-[[(2-nitrophenyl)amino]thioxomethyl]-
• CAS NO: 66934-10-9
• Molecular Formula: C14H11N3O3S
• Molecular Weight: 301.326
• Mol File: 66934-10-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[[(2-nitrophenyl)amino]thioxomethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[[(2-nitrophenyl)amino]thioxomethyl]-(66934-10-9)
• EPA Substance Registry System: Benzamide, N-[[(2-nitrophenyl)amino]thioxomethyl]-(66934-10-9)

Safety Data

• Hazardous Substances Data: 66934-10-9(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 88-74-4 2-nitro-aniline 
• 1147550-11-5 ammonium thiocyanate 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 100856-57-3 N-(4-nitrobenzo[d]thiazol-2-yl)benzamide 
• 85285-69-4 Nd⁽³⁺⁾*C₁₄H₉N₃O₃S^(2-)*Cl^(1-)*H₂O=Nd(C₁₄H₉N₃O₃S)Cl*H₂O 
• 85285-57-0 La⁽³⁺⁾*C₁₄H₉N₃O₃S^(2-)*Cl^(1-)*H₂O=La(C₁₄H₉N₃O₃S)Cl*H₂O 
• 85285-63-8 Pr⁽³⁺⁾*C₁₄H₉N₃O₃S^(2-)*Cl^(1-)*H₂O=Pr(C₁₄H₉N₃O₃S)Cl*H₂O 
• 80849-56-5 [Cu(C₆H₅CONHCSNHC₆H₄NO₂)2(ClO₄)2] 
• 1391013-09-4 N-(4-amino-3-(2-nitro-phenyl)-5-phenyl-3H-thiazol-2-ylidine)-benzamide 
• 51039-84-0 N-(2-nitrophenyl)thiourea 
• 21578-47-2 1-phenylcarbonyl-3-(2'-aminophenyl)thiourea 
• 85285-81-0 gadolinium (N-benzoyl-N'-orthonitrophenyl thiocarbamide) chloride hydrate 
• 85285-63-8 praseodymium (N-benzoyl-N'-orthonitrophenyl thiocarbamide) chloride hydrate 
• 85285-57-0 lanthanum (N-benzoyl-N'-orthonitrophenyl thiocarbamide) chloride hydrate 
• 85285-69-4 neodymium (N-benzoyl-N'-orthonitrophenyl thiocarbamide) chloride hydrate 
• 85285-75-2 samarium (N-benzoyl-N'-orthonitrophenyl thiocarbamide) chloride hydrate 
• 80849-60-1 [Cu(C₆H₅CONHCSNHC₆H₄NO₂)2(SCN)2] 

Relevant articles and documents

Iodine-mediated multi-component reactions: Readily access to tetrazoles and guanidines

Environmentally benign syntheses of One-pot sequential reactions of benzoyl chloride with amines followed by the treatment of molecular I2 reagent under basic conditions provide benzoyl tetrazoles and guanidines in moderate to excellent yields. This one-pot synthesis has several advantages such as mild reaction conditions, short reaction time, convenient workup, high yields, using cheap and readily available reagent molecular Iodine. In addition, functional group tolerance has been explored.

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Design, synthesis and algicides activities of thiourea derivatives as the novel scaffold aldolase inhibitors

By using a new Fragment-Based Virtual Screen strategy, two series of novel FBA-II inhibitors (thiourea derivatives) were de novo discovered based on the active site of fructose-1, 6-bisphosphate aldolase from Cyanobacterial (CyFBA). In comparison, most of the N-(2-benzoylhydrazine-1-carbonothioyl) benzamide derivatives (L14～L22) exhibit higher CyFBA-II inhibitory activities compared to N-(phenylcarbamothioyl) benzamide derivatives (L1～L13). Especially, compound L14 not only shows higher CyFBA-II activity (Ki = 0.65 μM), but also exhibits most potent in vivo activity against Synechocystis sp. PCC 6803 (EC50 = 0.09 ppm), higher (7-fold) than that of our previous inhibitor (EC50 = 0.6 ppm). The binding modes of compound L14 and CyFBA-II were further elucidated by jointly using DOX computational protocol, MM-PBSA and site-directed mutagenesis assays. The positive results suggest that strategy adopted in this study was promising to rapidly discovery the potent inhibitors with novel scaffolds. The satisfactory algicide activities suggest that the thiourea derivatives is very likely to be a promising lead for the development of novel specific algicides to solve Cyanobacterial harmful algal blooms (CHABs).