66938-86-1Relevant articles and documents
A catalytic hydrogenation preparing high-purity (3,4-diamino-phenyl) (4-fluoro phenyl) ketone method
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Paragraph 0023, (2017/02/28)
The invention relates to a method for preparing high-purity (3,4-diaminophenyl)(4-fluorophenyl) ketone by virtue of catalytic hydrogenation, belonging to the technical field of pharmaceutical and chemical engineering. The method comprises the following steps: adding (4-amino-3-nitrophenyl)(4-fluorophenyl) ketone (I) and a catalyst into an organic solvent, introducing hydrogen, and performing hydrogenation reduction reaction to obtain a flubendazole intermediate namely (3,4-diaminophenyl)(4-fluorophenyl) ketone (II). The method disclosed by the invention has the advantages that compared with a reduction method using sodium hydrosulfide, the method is simple in process, small in solvent dosage and short in reaction time, can be used for solving the problem that a large amount of sulfide-containing wastewater is difficult to be treated, and is beneficial for industrial production; meanwhile, a novel catalyst preparation method is simple, and has the characteristics of high reaction activity, good selectivity and recycled catalyst; compared with a pure Pt/C catalyst, the novel catalyst can be used for effectively inhibiting the phenomenon that carbanyl groups are reduced into methylene and inhibiting the occurrence of the defluorination phenomenon, and is relatively high in product yield and purity.
Anti-viral compounds
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, (2008/06/13)
The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.
Antirhino/enteroviral vinylacetylene benzimidazoles: A study of their activity and oral plasma levels in mice
Tebbe, Mark J.,Spitzer, Wayne A.,Victor, Frantz,Miller, Shawn C.,Lee, Chris C.,Sattelberg Sr., Thomas R.,McKinney, Emma,Tang, Joseph C.
, p. 3937 - 3946 (2007/10/03)
In an effort to find an orally bioavailable antiviral for the treatment of rhino/enteroviral infections, a series of vinylacetylene benzimidazoles (11a-o, 12, and 18a) was made. Initial studies of this class of antivirals showed that fluorine substitution on the left-hand phenyl ring in combination with the vinylacetylene moiety gave the requisite mix of physical properties to achieve good in vitro antiviral activity as well as respectable oral bioavailability in rhesus monkeys. To ascertain the generality of this finding and to broaden the scope of the structure-activity relationship (SAR), the present study concentrated on fluoro substitution of this class of molecules. The initial antiviral activity for each analogue was measured using human rhinovirus 14 (HRV-14). This served as an indicator of general antiviral activity for SAR purposes. Subsequently, the spectrum of antirhino/enteroviral activity of the more interesting analogues was evaluated through testing against a panel of seven additional rhino/enteroviruses. Broad-spectrum activity was present and consistent for all analogues tested, and it tracked closely with the antiviral activity observed against HRV-14. A simple screening protocol for oral bioavailability was established whereby compounds were administered orally to mice and plasma levels were measured. This procedure facilitated the evaluation of numerous analogues in a rapid manner. The C(max) was used as a measure of oral bioavailability to allow relative ranking of compounds. In general, fluorine substitution directly on the left-hand aromatic ring does give good oral blood levels. However, fluorine incorporation at other positions in the molecule was not as effective at maintaining either the activity or the oral plasma levels. The constructive combination of activity and oral plasma levels was maximized in three derivatives: 11a,e,g.
