66946-81-4

Basic information

• Product Name: 3-FLUOROINDOLE
• Synonyms: 3-FLUOROINDOLE;3-Fluoro-1H-indole
• CAS NO: 66946-81-4
• Molecular Formula: C₈H₆FN
• Molecular Weight: 135.14
• Mol File: 66946-81-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258.047 °C at 760 mmHg
• Flash Point: 109.863 °C
• Appearance: /
• Density: 1.274 g/cm³
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 3-FLUOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROINDOLE(66946-81-4)
• EPA Substance Registry System: 3-FLUOROINDOLE(66946-81-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 66946-81-4(Hazardous Substances Data)

Usage

General Description

3-Fluoroindole is a chemical compound that belongs to the indole family, which is a heterocyclic compound containing a pyrrole ring. It is specifically classified as a halogenated indole, with a fluorine atom attached to the third carbon position of the indole ring. 3-Fluoroindole is often used as a building block in organic synthesis and pharmaceutical research, as its fluorine atom can alter the chemical and physical properties of the indole ring, leading to potential applications in drug discovery and development. Additionally, 3-fluoroindole has been found to exhibit pharmacological activity, making it a valuable tool in medicinal chemistry and bioorganic chemistry research.

InChI:InChI=1/C8H6FN/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H

Upstream product

• 197067-27-9 3,3-difluoro-1,3-dihydro-2H-indol-2-one 
• 91-56-5 indole-2,3-dione 
• 771-50-6 1H-indole-3-carboxylic acid 

Relevant articles and documents

Compound containing indole ring structure, preparation method and application of compound, and bactericide

The invention belongs to the field of pesticides and discloses a compound containing an indole ring structure, a preparation method and application of the compound and a bactericide. The compound has the structure shown in the formula (I), and the compound has an excellent prevention and treatment effect on cucumber downy mildew, is equivalent to the current commercial oomycete disease prevention and treatment agent oxathiapiprolin, and has a good market development prospect.

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.

A synthesis of 3-fluoroindoles and 3,3-difluoroindolines by reduction of 3,3-difluoro-2-oxindoles using a borane tetrahydrofuran complex

A borane tetrahydrofuran complex has been used to study the reduction of 3,3-difluoro-2-oxindoles and been found to yield either 3-fluoroindoles or 3,3-difluoroindolines. The latter have been found to be reasonably stable when the aromatic nucleus is subs