6701-39-9Relevant articles and documents
In vitro studies of maleidride-forming enzymes
Yin, Sen,Friedrich, Steffen,Hrupins, Vjaceslavs,Cox, Russell J.
, p. 14922 - 14931 (2021/05/19)
In vitro assays of enzymes involved in the biosynthesis of maleidrides from polyketides in fungi were performed. The results show that the enzymes are closely related to primary metabolism enzymes of the citric acid cycle in terms of stereochemical preferences, but with an expanded substrate selectivity. A key citrate synthase can react both saturated and unsaturated acyl CoA substrates to give solely anti substituted citrates. This undergoes anti-dehydration to afford an unsaturated precursor which is cyclised in vitro by ketosteroid-isomerase-like enzymes to give byssochlamic acid. This journal is
Identification of middle chain fatty Acyl-CoA Ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for Polyketide extender unit
Miyazawa, Takeshi,Takahashi, Shunji,Kawata, Akihiro,Panthee, Suresh,Hayashi, Teruo,Shimizu, Takeshi,Nogawa, Toshihiko,Osada, Hiroyuki
, p. 26994 - 27011 (2015/11/17)
Background: Fatty acyl-CoA ligases involved in polyketide biosynthesis remain uncharacterized. Results: RevS classified in fatty acyl-AMP ligase clade was the middle chain fatty acyl-CoA ligase. Conclusion: RevS was responsible for 2-alkylmalonyl-CoA bios
Multiplexing of combinatorial chemistry in antimycin biosynthesis: Expansion of molecular diversity and utility
Yan, Yan,Chen, Jing,Zhang, Lihan,Zheng, Qingfei,Han, Ying,Zhang, Hua,Zhang, Daozhong,Awakawa, Takayoshi,Abe, Ikuro,Liu, Wen
supporting information, p. 12308 - 12312 (2013/12/04)
Diversity-oriented biosynthesis of a library of antimycin-like compounds (380 altogether) was accomplished by using multiplex combinatorial biosynthesis. The core strategy depends on the use of combinatorial chemistry at different biosynthetic stages. This approach is applicable for the diversification of polyketides, nonribosomal peptides, and the hybrids that share a similar biosynthetic logic. Copyright