67031-08-7

Basic information

• Product Name: methyl 2-(4-fluorophenyl)pent-4-enoate
• CAS NO: 67031-08-7
• Molecular Formula: C₁₂H₁₃FO₂
• Molecular Weight: 208.2288
• Mol File: 67031-08-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 240.2°C at 760 mmHg
• Flash Point: 96.3°C
• Density: 1.085g/cm³
• Vapor Pressure: 0.0385mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: methyl 2-(4-fluorophenyl)pent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-fluorophenyl)pent-4-enoate(67031-08-7)
• EPA Substance Registry System: methyl 2-(4-fluorophenyl)pent-4-enoate(67031-08-7)

Safety Data

• Hazardous Substances Data: 67031-08-7(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 106-95-6 allyl bromide 
• 405-50-5 p-Fluorophenylacetic acid 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 

Downstream Products

• 67031-14-5 methyl 2-(4-fluorophenyl)-4-oxobutanoate 
• 51230-93-4 2-(4-fluorophenyl)pent-4-enoic acid 
• 301854-27-3 3-(4-fluorophenyl)-5-methyltetrahydrofuran-2-one 
• 67031-20-3 Methyl-2-(p-fluorphenyl)-1-succinat 
• 67030-97-1 Methyl-2-(p-fluorphenyl)-3-formylacrylat 

Relevant articles and documents

Synthesis and structure-antifungal activity relationships of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues: Further refinement of tentative pharmacophore group

Two series of 3-(substituted phenyl)-5-alkyl-2,5-dihydrofuran-2-ones related to a natural product, (-)incrustoporine, were synthesized and their in vitro antifungal activity evaluated. The compounds with halogen substituents on the phenyl ring exhibited selective antifungal activity against the filamentous strains of Absidia corymbifera and Aspergillus fumigatus. On the other hand, the influence of the lenghth of the alkyl chain at C(5) was marginal. The antifungal effect of the most active compound against the above strains was higher than that of ketoconazole, and close to that of amphotericin B. In order to verify the hypothesis about a possible relationship between the Michael-accepting ability of the compounds and their antifungal activity, a series of simple carbanalogues, 2-(substituted phenyl)cyclopent-2-enones, was prepared and subjected to antifungal activity assay as well.