670748-78-4

Basic information

• Product Name: Propanedioic acid, [(2-chlorophenyl)methyl]-, dimethyl ester
• CAS NO: 670748-78-4
• Molecular Formula: C12H13ClO4
• Molecular Weight: 256.686
• Mol File: 670748-78-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(2-chlorophenyl)methyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(2-chlorophenyl)methyl]-, dimethyl ester(670748-78-4)
• EPA Substance Registry System: Propanedioic acid, [(2-chlorophenyl)methyl]-, dimethyl ester(670748-78-4)

Safety Data

• Hazardous Substances Data: 670748-78-4(Hazardous Substances Data)

Upstream product

• 18424-76-5 dimethyl malonate sodium salt 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 108-59-8 malonic acid dimethyl ester 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 18424-76-5 sodiodimethylmalonate 
• 105-53-3 diethyl malonate 

Relevant articles and documents

Palladium(0)-Catalyzed Enantioselective Intramolecular Arylation of Enantiotopic Secondary C?H Bonds

The enantioselective functionalization of nonactivated enantiotopic secondary C?H bonds is one of the greatest challenges in transition-metal-catalyzed C?H activation proceeding by an inner-sphere mechanism. Such reactions have remained elusive within the realm of Pd0 catalysis. Reported here is the unique reactivity profile of the IBiox ligand family in the Pd0-catalyzed intramolecular arylation of such nonactivated secondary C?H bonds. Chiral C2-symmetric IBiox ligands led to high enantioselectivities for a broad range of valuable indane products containing a tertiary stereocenter, as well as the arylation of secondary C?H bonds adjacent to amides. Depending on the amide substituents and upon control of reaction time, indanes containing labile tertiary stereocenters were also obtained with high enantioselectivities. Analysis of the steric maps of the IBiox ligands indicated that the level of enantioselectivity correlates with the difference between the two most occupied and the two less occupied space quadrants, and provided a blueprint for the design of even more efficient ligands.

A facile one-pot benzylation of sodium enolates using trifluoromethansulfonic anhydride and diphenyl sulfoxide

A facile one-pot C-benzylation reaction proceeded smoothly and in good yields by treating various sodium enolates and benzyl alcohol with in situ generated alkoxy diphenyl sulfonium salt derived from trifluoromethansulfonic anhydride and diphenyl sulfoxide.