67082-00-2

Basic information

• Product Name: 3-PHENYL-4'-TRIFLUOROMETHYLPROPIOPHENONE
• Synonyms: 3-PHENYL-4'-TRIFLUOROMETHYLPROPIOPHENONE
• CAS NO: 67082-00-2
• Molecular Formula: C₁₆H₁₃F₃O
• Molecular Weight: 278.27
• Mol File: 67082-00-2.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 373.93°C at 760 mmHg
• Flash Point: 196.618°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 3-PHENYL-4'-TRIFLUOROMETHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-4'-TRIFLUOROMETHYLPROPIOPHENONE(67082-00-2)
• EPA Substance Registry System: 3-PHENYL-4'-TRIFLUOROMETHYLPROPIOPHENONE(67082-00-2)

Safety Data

• Hazardous Substances Data: 67082-00-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H13F3O/c17-16(18,19)14-9-7-13(8-10-14)15(20)11-6-12-4-2-1-3-5-12/h1-5,7-10H,6,11H2

Upstream product

• 157731-58-3 2-<4-(Trifluoromethyl)phenyl>-1,3,2-dioxaborolane 
• 346608-05-7 3-phenylpropionic acid 2-pyridinylmethyl ester 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 100-51-6 benzyl alcohol 
• 104-53-0 3-phenyl-propionaldehyde 
• 98-56-6 4-chlorobenzotrifluoride 
• 501374-30-7 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 91-01-0 1,1-Diphenylmethanol 
• 100-52-7 benzaldehyde 
• 124-38-9 carbon dioxide 
• 17376-04-4 2-phenethyl iodide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 705-31-7 4-trifluoromethylphenylacetylene 

Downstream Products

• 113793-11-6 3-(4-(trifluoromethyl)phenyl)-1H-indene 
• 1436413-23-8 3-benzyl-2-[4′-(trifluoromethyl)phenyl]quinoline 

Relevant articles and documents

Synthesis of α-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols

A new method for converting terminal epoxides and primary alcohols into α-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.

Borane-Catalyzed, Chemoselective Reduction and Hydrofunctionalization of Enones Enabled by B-O Transborylation

The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.

Efficient Generation and Synthetic Applications of Alkyl-Substituted Siloxycarbenes: Suppression of Norrish-Type Fragmentations of Alkanoylsilanes by Triplet Energy Transfer

Acylsilanes have been known to undergo isomerization to siloxycarbenes under photoirradiation and the thus generated carbenes can be utilized for various synthetic reactions. But this carbene formation is not necessarily efficient with some alkanoylsilanes because Norrish-type fragmentations compete, which limit the synthetic utility of alkanoylsilanes as carbene precursors. In this study, generation of siloxycarbenes from alkanoylsilanes by visible-light-induced energy transfer was examined by using an Ir complex, [Ir{dF(CF3)ppy}2(dtbpy)]PF6, and was successfully applied to the C?C coupling reactions with boronic esters or aldehydes. This methodology efficiently suppressed undesired Norrish-type reactions and broadened synthetic utility of alkanoylsilanes.