67083-40-3

Basic information

• Product Name: Benzene, 1,3-dimethyl-5-nitroso-
• CAS NO: 67083-40-3
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Mol File: 67083-40-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dimethyl-5-nitroso-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dimethyl-5-nitroso-(67083-40-3)
• EPA Substance Registry System: Benzene, 1,3-dimethyl-5-nitroso-(67083-40-3)

Safety Data

• Hazardous Substances Data: 67083-40-3(Hazardous Substances Data)

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 68395-77-7 N-(3,5-dimethylphenyl)hydroxylamine 
• 99-12-7 5-nitro-m-xylene 

Downstream Products

• 610756-21-3 (2,6-Me2C6H3NC(Me)CHC(Me)NC6H3Me2-2,6)Ni(η2-N-(C6H3Me2-3,5)-N-nitrosohydroxylaminato) 
• 1373117-76-0 5,7-dimethyl-3-phenylquinoline 
• 77611-71-3 (E)-1,2-bis(3,5-dimethylphenyl)diazene 

Relevant articles and documents

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-of-Equilibrium Enzymatic Reactions

Ultrasensitivity is a ubiquitous emergent property of biochemical reaction networks. The design and construction of synthetic reaction networks exhibiting ultrasensitivity has been challenging, but would greatly expand the potential properties of life-like materials. Herein, we exploit a general and modular strategy to reversibly regulate the activity of enzymes using light and show how ultrasensitivity arises in simple out-of-equilibrium enzymatic systems upon incorporation of reversible photoswitchable inhibitors (PIs). Utilizing a chromophore/warhead strategy, PIs of the protease α-chymotrypsin were synthesized, which led to the discovery of inhibitors with large differences in inhibition constants (Ki) for the different photoisomers. A microfluidic flow setup was used to study enzymatic reactions under out-of-equilibrium conditions by continuous addition and removal of reagents. Upon irradiation of the continuously stirred tank reactor with different light pulse sequences, i.e., varying the pulse duration or frequency of UV and blue light irradiation, reversible switching between photoisomers resulted in ultrasensitive responses in enzymatic activity as well as frequency filtering of input signals. This general and modular strategy enables reversible and tunable control over the kinetic rates of individual enzyme-catalyzed reactions and makes a programmable linkage of enzymes to a wide range of network topologies feasible.

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

Rh(III)-Catalyzed bilateral cyclization of aldehydes with nitrosos toward unsymmetrical acridines proceeding with C-H functionalization enabled by a transient directing group

A Rh(iii)-catalyzed bilateral cyclization was developed for the efficient construction of acridines proceeding with C-H functionalization whereby in situ formation and removal of an imino transient directing group in the presence of catalytic amount of BnNH2 are achieved. In this transformation, a sequential Rh(iii)-catalyzed C-H amination, cyclization, and aromatization process was involved.