67092-18-6

Basic information

• Product Name: 2,6-dichloroquinazoline
• Synonyms: 2,6-dichloroquinazoline;Quinazoline, 2,6-dichloro-
• CAS NO: 67092-18-6
• Molecular Formula: C₈H₄Cl₂N₂
• Molecular Weight: 199.03676
• EINECS: -0
• Mol File: 67092-18-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 164 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 287.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.486±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: -0.50±0.30(Predicted)
• CAS DataBase Reference: 2,6-dichloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloroquinazoline(67092-18-6)
• EPA Substance Registry System: 2,6-dichloroquinazoline(67092-18-6)

Safety Data

• Hazardous Substances Data: 67092-18-6(Hazardous Substances Data)

Usage

General Description

2,6-dichloroquinazoline is a heterocyclic chemical compound with a quinazoline backbone and chlorine atoms at the 2 and 6 positions. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Due to its structural properties, it can be modified to create a wide range of derivatives with varying properties and applications. 2,6-dichloroquinazoline is highly reactive and can undergo various chemical reactions, making it a versatile building block for the production of diverse compounds. It is also used in research and development as a starting material for the synthesis of new molecules with potential therapeutic or industrial applications.

Upstream product

• 60610-12-0 6-Chlor-2-oxo-1,2-dihydrochinazolin 
• 96515-79-6 5-chloro-2-fluorobenzaldehyde 
• 20028-71-1 6-chloroquinazolin-2-amine 
• 20028-68-6 2,4,6-trichloroquinazoline 

Downstream Products

• 81585-59-3 4-[N-(6-chloroquinazolin-2-yl)-N-methyl amino]phenol 
• 108-95-2 phenol 

Relevant articles and documents

OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.

Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands

The 5-HT3 receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therapeutic target. During a recent fragment screen, 6-chloro-N-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine (1) was identified as a 5-HT3R hit fragment. Here we describe the synthesis and structure-activity relationships (SAR) of a series of (iso)quinoline and quinazoline compounds that were synthesized and screened for 5-HT3R affinity using a [3H]granisetron displacement assay. These studies resulted in the discovery of several high affinity ligands of which compound 22 showed the highest affinity (pKi > 10) for the 5-HT3 receptor. The observed SAR is in agreement with established pharmacophore models for 5-HT3 ligands and is used for ligand-receptor binding mode prediction using homology modeling and in silico docking approaches.

Pyri(mi)dyl-oxy-and -thio-benzoic acid derivatives useful as herbicides and plant growth regulants

New pyri(mi)dyl-oxy- or -thio-benzoic acid derivatives of the formula STR1 are taught which have herbicidal and plant growth regulating activity. In the formula Z can be Ch or N, X is oxygen or sulphur, A is oxygen, sulphur, a radical R5 --N=or a radical R6 O--N=and B is oxygen, sulphur, a radical STR2 with the proviso that at least one of the radicals R1, R2 or R3 represents alkyl or a part of a 3- to 6-membered fused carbocyclic ring.