671246-69-8

Basic information

• Product Name: 1H-Pyrazole, 3,5-bis(1-methylethyl)-1-[2-[(4-methylphenyl)sulfonyl]ethyl]-
• CAS NO: 671246-69-8
• Molecular Formula: C18H26N2O2S
• Molecular Weight: 334.483
• Mol File: 671246-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 3,5-bis(1-methylethyl)-1-[2-[(4-methylphenyl)sulfonyl]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 3,5-bis(1-methylethyl)-1-[2-[(4-methylphenyl)sulfonyl]ethyl]-(671246-69-8)
• EPA Substance Registry System: 1H-Pyrazole, 3,5-bis(1-methylethyl)-1-[2-[(4-methylphenyl)sulfonyl]ethyl]-(671246-69-8)

Safety Data

• Hazardous Substances Data: 671246-69-8(Hazardous Substances Data)

Upstream product

• 5535-52-4 tolyl vinyl sulfone 
• 18362-64-6 2,6-dimethyl-3,5-heptanedione 
• 671246-67-6 [2-(p-tosyl)-ethyl]-hydrazine 

Downstream Products

• 17536-00-4 3,5-diisopropylpyrazole 

Relevant articles and documents

Synthesis of β-tosylethylhydrazine and its use in preparation of N-protected pyrazoles and 5-aminopyrazoles

β-Tosylethylhydrazine (6) can be prepared efficiently in one step from commercially available p-tolyl vinyl sulfone (7) and hydrazine hydrate. This hydrazine reacts with both 1,3-diketones and conjugated ynones in glacial acetic acid to provide a variety of N-tosylethyl-protected (TSE) pyrazoles in good yields. The TSE group can be removed from the pyrazoles using potassium t-butoxide in THF at -30°C-rt. In addition, hydrazine 6 condenses with β-ketonitriles and β-aminoacrylonitriles to afford 5-aminopyrazoles, which can be deprotected by brief treatment with NaOEt in EtOH/DMSO at 45°C.