6714-68-7

Basic information

• Product Name: SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE
• Synonyms: SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE;2'-spiro[1,3-dioxolane-2,3'-indoline]one;Indol-2(3H)-one, 3,3-ethylenedioxy-;Spiro[1,3-dioxolane-2,3'-[3H]indol]-2'(1'H]-one;spiro[1,3-dioxolane-2,3'-1H-indole]-2'-one;spiro[1,3-dioxolane-2,3'-indoline]-2'-one;5'-bromospiro[[1,3]dioxolane-2,3'-indolin]-2'-one
• CAS NO: 6714-68-7
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Mol File: 6714-68-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE(6714-68-7)
• EPA Substance Registry System: SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE(6714-68-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6714-68-7(Hazardous Substances Data)

Usage

General Description

SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE is a chemical compound with a complex and unique structure. It contains a spirolactone ring fused with a dioxolane ring and an indolin-2-one ring. SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE has potential applications in pharmaceuticals and organic synthesis due to its interesting structure and potential biological activity. The incorporation of the spirolactone ring can impart specific properties and functions to the compound, making it valuable for drug discovery and development. Further research is needed to explore the full potential of SPIRO-(1,3-DIOXOLANE-2,3'INDOLIN)-2'-ONE and its possible applications in various fields.

Upstream product

• 91-56-5 indole-2,3-dione 
• 107-21-1 ethylene glycol 
• 107-07-3 2-chloro-ethanol 
• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 139017-66-6 1-<<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>-methyl>cyclohexanecarbonitrile 
• 113549-04-5 1'-benzylspiro(1,3-dioxolane-2,3'-indolin)-2'-one 
• 300588-82-3 β-ethylenacetal of 1-(3,3-dimethyl-2-oxobutyl)indole-2,3-dione 
• 75822-32-1 1′-(2-(4-bromophenyl)-2-oxoethyl)spiro[[1,3]dioxolane-2,3′-indolin]-2′-one 
• 623567-19-1 [2-(2-hydroxymethyl-[1,3]dioxolan-2-yl)-phenyl]-carbamic acid ethyl ester 
• 365222-73-7 2-(2-tert-butoxycarbonylamino-phenyl)-[1,3]dioxolane-2-carboxylic acid 
• 365222-74-8 2-[2-(allyl-tert-butoxycarbonyl-amino)-phenyl]-[1,3]dioxolane-2-carboxylic acid 
• 365222-65-7 [2-(2-acryloyl-[1,3]dioxolan-2-yl)-phenyl]-allyl-carbamic acid tert-butyl ester 
• 365222-75-9 allyl-{2-[2-(methoxy-methyl-carbamoyl)-[1,3]dioxolan-2-yl]-phenyl}-carbamic acid tert-butyl ester 
• 365222-64-6 2-[2-(allyl-tert-butoxycarbonyl-amino)-phenyl]-[1,3]dioxolane-2-carboxylic acid allyl ester 
• 214417-82-0 1-(3,3-dimethyl-2-oxobutyl)indole-2,3-dione 
• 85233-38-1 2,3,4,10-tetrahydro-3,3-dimethyl-10-phenylpyrimido[1,2-a]indol-10-ol 
• 139018-00-1 10-Cyclohexylmethyl-2,3,4,10-tetrahydro-pyrimido[1,2-a]indol-10-ol 
• 139017-98-4 10-Cyclohexylmethyl-3,3-dimethyl-2,3,4,10-tetrahydro-pyrimido[1,2-a]indol-10-ol 

Relevant articles and documents

Design, synthesis, computational and biological evaluation of new anxiolytics

New anxiolytics have been discovered by prediction of biological activity with computer programs pass and derek for a heterogeneous set of 5494 highly chemically diverse heterocyclic compounds (thiazoles, pyrazoles, isatins, a-fused imidazoles and others)

Triarylethylene-indolin-2,3-dione molecular conjugates: Design, synthesis, docking studies and anti-proliferation evaluation

A series of 1H-1,2,3-triazole-linked ospemifene-isatin and O-methylated ospemifene-isatin conjugates were synthesized and assayed for their anti-proliferative activities against estrogen-responsive as well as estrogen-non-responsive cells. The non-cytotoxic conjugate 14e, with an optimal combination of bromo substituents at the C-5/C-7 positions of isatin, proved to be a promising hit with an IC50 value of 31.62 μM against MCF-7 and 19.23 μM against MDA-MB-231. The observed anti-proliferative activities of active conjugates were further corroborated via docking studies carried out on estrogen receptor subtypes α and β.

Strategic synthesis and in vitro antimicrobial evaluation of novel difluoromethylated 1-(1, 3-diphenyl-1H-pyrazol-4-yl)-3, 3-difluoro-1, 3-dihydro-indol-2-ones

A strategic synthesis of 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3,3-difluoro-1,3-dihydro-indol-2-ones has been achieved by the reaction of indole-2,3-dione (isatin) and substituted bromoacetyl benzene followed by cyclization reaction and evaluated for in vitro antibacterial and antifungal activities. Direct fluorination using diethylaminosulfur trifluoride as a nucleophilic fluorinating reagent was carried out in the present paper. Undoubtedly this methodology gives a facile and straightforward pathway to construct 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3,3-difluoro-1,3-dihydro-indol-2-ones in good yields. The structure of new fluorinated 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3,3-difluoro-1,3-dihydro-indol-2-ones was characterized based on 1H, 13C, and 19F nuclear magnetic resonance spectroscopy and mass spectrometry data. Structure of target compound was confirmed by Nuclear Overhauser Effect Spectroscopy spectra. Some of the synthesized compounds showed good antimicrobial activities against bacteria and fungi.

Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation

To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.