67152-20-9

Basic information

• Product Name: 2,4-DIFLUORO-5-NITROBENZONITRILE
• Synonyms: 2,4-DIFLUORO-5-NITROBENZONITRILE;5-Cyano-2,4-difluoronitrobenzene;2,4-Difluoro-5-ntirobenzonitrile
• CAS NO: 67152-20-9
• Molecular Formula: C₇H₂F₂N₂O₂
• Molecular Weight: 184.1
• Product Categories: Aromatic Nitriles
• Mol File: 67152-20-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 271.5 °C at 760 mmHg
• Flash Point: 118 °C
• Appearance: /
• Density: 1.51 g/cm³
• Vapor Pressure: 0.00642mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,4-DIFLUORO-5-NITROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUORO-5-NITROBENZONITRILE(67152-20-9)
• EPA Substance Registry System: 2,4-DIFLUORO-5-NITROBENZONITRILE(67152-20-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 67152-20-9(Hazardous Substances Data)

Usage

Description

2,4-Difluoro-5-nitrobenzonitrile is an organic compound characterized by the presence of fluorine and nitro groups attached to a benzene ring, with a nitrile functional group. It is a key intermediate in the synthesis of various pharmaceuticals and chemical compounds.

Uses

Used in Pharmaceutical Industry:
2,4-Difluoro-5-nitrobenzonitrile is used as a key intermediate in the synthesis of potent and selective tankyrase inhibitors. These inhibitors play a crucial role in the inhibition of tumorigenesis by targeting tankyrase enzymes, which are involved in cell proliferation, apoptosis, and Wnt signaling pathways. By inhibiting tankyrase enzymes, these compounds can potentially lead to the suppression of tumor growth and the development of new therapeutic strategies for cancer treatment.

InChI:InChI=1/C7H2F2N2O2/c8-5-2-6(9)7(11(12)13)1-4(5)3-10/h1-2H

Upstream product

• 3939-09-1 2,4-difluorobenzonitrile 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 72482-64-5 2,4-difluorobenzoyl chloride 
• 85118-02-1 2,4-difluorobenzamide 
• 1242269-80-2 2-fluoro-4-chloro-5-nitrobenzonitrile 

Downstream Products

• 143151-03-5 4-amino-2-fluoro-5-nitrobenzonitrile 
• 952285-54-0 5-amino-2,4-difluorobenzonitrile 
• 226701-59-3 2-fluoro-4,5-diaminobenzonitrile 
• 497147-91-8 2-fluoro-4,5-diaminobenzamidine 

Relevant articles and documents

Preparation method of fluorine-containing aryl compound

The invention relates to the field of organic synthesis, and especially relates to a preparation method of a fluorine-containing aryl compound. The invention provides a preparation method of a compound as shown in a formula 1. The preparation method comprises the following steps: fluorination reaction: reacting a compound as shown in a formula 2 with alkali metal fluoride in the presence of a phase transfer catalyst to prepare the compound as shown in the formula 1. According to the preparation method of the fluorine-containing aryl compound provided by the invention, a reaction system does not contain a solvent, the boiling point of the phase transfer catalyst is relatively high, solvent interference is avoided during rectification or short steaming after the reaction is finished, the distillation yield is high, and the product purity is good.

CHEMICAL COMPOUNDS

This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.