67171-13-5

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane, 8-methyl-3,3-diphenyl-
• CAS NO: 67171-13-5
• Molecular Formula: C20H23N
• Molecular Weight: 277.409
• Mol File: 67171-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane, 8-methyl-3,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane, 8-methyl-3,3-diphenyl-(67171-13-5)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane, 8-methyl-3,3-diphenyl-(67171-13-5)

Safety Data

• Hazardous Substances Data: 67171-13-5(Hazardous Substances Data)

Upstream product

• 532-24-1 tropinone 
• 71-43-2 benzene 

Relevant articles and documents

Synthesis of aryl-substituted piperidines by superacid activation of piperidones

Diarylpiperidines (8-12) may be prepared in good to excellent yields (80-99%) by the reaction of piperidones (3d-h) with benzene and the Bronsted superacid, trifluoromethanesulfonic acid (CF3-SO3H, TfOH). Tropinone (6) and quinuclidone (7) also react in good yields with benzene in TfOH to give the condensation products (13 and 14). Ketal and acetal derivatives also give condensation products (8 and 24) upon reaction with C6H6 in TfOH. The conversion of 3g to 11 is sensitive to both acid quantity and acid strength; a mechanism is proposed for the conversion that invokes dicationic intermediates.