671815-99-9

Basic information

• Product Name: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid
• Synonyms: trans-4-[(1R)-1-[[(1,1-DiMethylethoxy)carbonyl]aMino]ethyl]cyclohexanecarboxylic Acid;trans-4-[(R)-1-[(tert-Butyloxycarbonyl)aMino]ethyl]cyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-[(1R)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]ethyl]-, trans-;e: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid;Y-27632 2HCl intermediates;Y-27632 dihydrochloride intermediates;(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid;(1R)-trans-4-[N-Boc-1-aMinoethyl]cyclohexanecarboxylic Acid (~90% R)
• CAS NO: 671815-99-9
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.3526
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents
• Mol File: 671815-99-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 125-128°C
• Boiling Point: 416.1±18.0 °C(Predicted)
• Appearance: /
• Density: 1.088±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate
• PKA: 4.85±0.10(Predicted)
• CAS DataBase Reference: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid(671815-99-9)
• EPA Substance Registry System: (1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid(671815-99-9)

Safety Data

• Hazardous Substances Data: 671815-99-9(Hazardous Substances Data)

Usage

Description

(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid is a white solid compound that serves as an intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. It is a significant molecule in the pharmaceutical industry due to its potential applications in developing treatments for various conditions.

Uses

Used in Pharmaceutical Industry:
(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid is used as an intermediate for the synthesis of Rho kinase inhibitors. Rho kinase inhibitors are essential in treating conditions such as hypertension, stroke, and other cardiovascular diseases by regulating the activity of Rho kinase, a protein involved in smooth muscle contraction and cell motility.
(1R)-trans-4-[N-Boc-1-aminoethyl]cyclohexanecarboxylic Acid is also used as an intermediate for the synthesis of neurite outgrowth promoters. These promoters play a crucial role in the development and repair of the nervous system, as they stimulate the growth and elongation of neurites, which are essential for the proper functioning of neurons.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 149004-75-1 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 36283-44-0 N-acetyl-1-phenylethylamine 
• 88146-37-6 (R)-N-(1-(4-acetylphenyl)ethyl)acetamide 
• 859163-61-4 (R)-4-(1-acetamidoethyl)benzoic acid 
• 1318865-17-6 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid methyl ester 
• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 32529-80-9 trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane 
• 183996-94-3 trans-4-acetylcyclohexanecarboxylic acid methyl ester 

Downstream Products

• 671816-04-9 trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 
• 129830-38-2 (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride 
• 1318865-29-0 C₁₉H₂₈FN₃O₃ 
• 1318865-32-5 C₁₉H₂₈FN₃O₃ 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF ULK1

The present technology is directed to compounds, compositions, and methods related to inhibition of ULK1 and treatment of cancers therefrom.

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro deriv