672-78-6

Basic information

• Product Name: METHYL P-TOLUENESULFINATE
• Synonyms: METHYL P-TOLUENESULFINATE;MGPLBSPZSIFUQX-UHFFFAOYSA-N
• CAS NO: 672-78-6
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.23
• Mol File: 672-78-6.mol
• Article Data: 75

Chemical Properties

• Boiling Point: 86-88 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: METHYL P-TOLUENESULFINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL P-TOLUENESULFINATE(672-78-6)
• EPA Substance Registry System: METHYL P-TOLUENESULFINATE(672-78-6)

Safety Data

• Hazardous Substances Data: 672-78-6(Hazardous Substances Data)

Usage

Uses

p-Toluenesulfinic Acid Methyl Ester is an intermediate in the synthesis of Sulfonamides.

Upstream product

• 186581-53-3 diazomethane 
• 536-57-2 p-toluene sulfinic acid 
• 67-56-1 methanol 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 4973-66-4 methyl thiotosylate 
• 68819-94-3 p-tolyl benzeneselenosulfonate 
• 25566-59-0 N-methyl-N-(2-phenethyl)-4-methylbenzenesulfonamide 
• 72818-30-5 Anisoyl-4-tolylsulfon 
• 128792-61-0 (bromo)(ethoxy) methyl 4-methylphenylsulfone 
• 112897-65-1 2-Thiabicyclo<2.2.1>heptan-6-on-2,2-dioxid-p-tolylsulfonylhydrazon 
• 15210-25-0 bicyclo[10.3.0]pentadec-1⁽¹²⁾-en-13-one 
• 1950-78-3 p-toluenesulfonyl iodide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 18137-96-7 nitromethane anion 

Downstream Products

• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 17530-89-1 p-tolyl phenacyl sulphoxide 
• 67-56-1 methanol 
• 6873-93-4 1-[(4-methylphenyl)sulfinyl]piperidine 
• 16066-33-4 4-<(4-methylphenyl)sulfinyl>morpholine 
• 114376-01-1 propyl 4-methylbenzenesulfinate 
• 116471-84-2 4-Methyl-benzenesulfinic acid (S)-allyl-methyl-amide 
• 130877-76-8 methyl 2,4-dimethoxy-6-(p-tolylsulfinyl) methyl benzoate 
• 134876-51-0 t-butylsulfonyl p-tolylsulfinyl methane 
• 86783-14-4 N,N-Dimethyl-N'-[2-(toluene-4-sulfinyl)-eth-(E)-ylidene]-hydrazine 
• 104871-67-2 (R)-2-(p-tolylsulfinyl)-1-cyclohexanone 
• 104871-69-4 2-((S)-Toluene-4-sulfinyl)-cyclohexanone 
• 82483-97-4 Phenyl-[1-phenyl-2-(toluene-4-sulfinyl)-eth-(Z)-ylidene]-amine 
• 129083-18-7 (+/-)-(phenylsulfonyl)(p-tolylsulfinyl)methane 

Relevant articles and documents

Direct C-H Thiolation for Selective Cross-Coupling of Arenes with Thiophenols via Aerobic Visible-Light Catalysis

An aerobic metal-free, visible-light-induced regioselective thiolation of phenols with thiophenols is reported. The cross-coupling protocol exhibits great functional group tolerance and high regioselectivity. Mechanistic studies reveal that the disulfide

N - P -Toluenesulfinylimidazole: A New in situ Reagent for the Mild and Efficient Synthesis of p -Toluenesulfinate Alkyl Esters and Aryl Esters

A new synthetic methodology has been developed for the synthesis of sulfinate alkyl and aryl esters. The methodology involves the combination of p -toluenesulfinic acid and 1,1′-carbonyldiimidazole (CDI) to create the putative reagent sulfinylimidazole. The process spontaneously releases carbon dioxide upon the addition of the CDI to the acid suggesting the rapid formation of the proposed reagent. Reaction of this reagent with a series of alcohols (primary, secondary, and tertiary) afforded the corresponding sulfinate alkyl esters in good to excellent yields by the addition of alcohols. It was also possible to form the related sulfinate aryl esters by treating the proposed sulfinylimidazole with selected phenols (phenol, p - tert -butylphenol, and thymol). The aryl esters were formed in excellent conversion based on analysis of the 500 MHz 1H NMR spectra of the crude reaction mixtures.

Direct synthesis of sulfinic esters via ultrasound accelerated tandem reaction of thiols and alcohols with N-bromosuccinimide

The direct transformation of various thiols and simple alcohols with N-bromosuccinimide into sulfinic esters has been investigated by using different categories of base/acidic catalysts as well as co-solvents under varied reaction conditions. The reaction was found out to afford the sulfinic esters with high yields in the absence of catalysts, especially within the shorter time under the acceleration of ultrasonic irradiation than under the longer-lasting conventional stirring conditions.