67214-11-3

Basic information

• Product Name: 7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID
• Synonyms: 7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID;4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 7-METHYL-4-OXO-;7-METHYL-4-OXO-4H-1-BENZOPYRAN-2-CARBOXYLIC ACID;OTAVA-BB 1023159;7-methyl-4-oxo-4H-chromene-2-carboxylic acid(SALTDATA: FREE)
• CAS NO: 67214-11-3
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.17882
• Mol File: 67214-11-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 367.153°C at 760 mmHg
• Flash Point: 148.453°C
• Appearance: /
• Density: 1.422g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID(67214-11-3)
• EPA Substance Registry System: 7-METHYL-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID(67214-11-3)

Safety Data

• Hazardous Substances Data: 67214-11-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H8O4/c1-6-2-3-7-8(12)5-10(11(13)14)15-9(7)4-6/h2-5H,1H3,(H,13,14)

Upstream product

• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 164171-54-4 5-(2-hydroxy-4-methylphenyl)-3-isoxazolecarboxylic acid 
• 79480-09-4 N-phenyl-7-methyl-4(H)-oxo-1-benzopyran-2-carboxamide 

Relevant articles and documents

Chromene-containing aromatic sulfonamides with carbonic anhydrase inhibitory properties

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the essential reaction of CO2 hydration in all living organisms, being actively involved in the regulation of a plethora of patho/physiological conditions. A series of chromene-based sulfonamides were synthesized and tested as possible CA inhibitors. Their inhibitory activity was assessed against the cytosolic human isoforms hCA I, hCA II and the transmembrane hCA IX and XII. Several of the investigated derivatives showed interesting inhibition activity towards the tumor associate isoforms hCA IX and hCA XII. Furthermore, computational procedures were used to investigate the binding mode of this class of compounds, within the active site of hCA IX.

SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.