67224-41-3 Usage
Description
ACTH (4-11) is a peptide fragment derived from adrenocorticotropic hormone (ACTH), a hormone present in the brain that plays a crucial role in the body's stress response. This specific fragment is known for its ability to induce melanocyte differentiation and inhibit angiotensin-converting enzyme (ACE) activity, making it a subject of interest for various applications in the medical and pharmaceutical fields.
Uses
Used in Pharmaceutical Industry:
ACTH (4-11) is used as a therapeutic agent for promoting melanocyte differentiation, which can be beneficial in treating conditions related to pigmentation disorders or skin damage. Its ability to induce melanocyte differentiation at a concentration of 1,000 nM makes it a potential candidate for skin-related treatments.
ACTH (4-11) is also used as an inhibitor of angiotensin-converting enzyme (ACE) activity in the pharmaceutical industry. With an IC50 value of 24 μM in homogenized canine lung, this peptide fragment can be utilized in the development of drugs targeting ACE, which is an important enzyme in the regulation of blood pressure and other physiological processes.
Used in Research and Development:
In the field of research and development, ACTH (4-11) serves as a valuable tool for determining the substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz). This application aids in understanding the interactions between the enzyme and its substrates, which can be crucial for the development of new drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 67224-41-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,2,2 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67224-41:
(7*6)+(6*7)+(5*2)+(4*2)+(3*4)+(2*4)+(1*1)=123
123 % 10 = 3
So 67224-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C50H71N15O11S/c1-77-21-18-33(52)43(69)61-36(16-17-42(67)68)46(72)65-40(24-31-26-55-28-59-31)48(74)63-38(22-29-10-3-2-4-11-29)47(73)62-35(15-9-20-56-50(53)54)45(71)64-39(23-30-25-57-34-13-6-5-12-32(30)34)44(70)58-27-41(66)60-37(49(75)76)14-7-8-19-51/h2-6,10-13,25-26,28,31,33,35-40,57H,7-9,14-24,27,51-52H2,1H3,(H,58,70)(H,60,66)(H,61,69)(H,62,73)(H,63,74)(H,64,71)(H,65,72)(H,67,68)(H,75,76)(H4,53,54,56)/t31?,33-,35-,36-,37-,38-,39-,40-/m0/s1
