6723-30-4

Basic information

• Product Name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
• Synonyms: HYDROXYLAMINE, O-(TETRAHYDRO-2H-PYRAN-2-YL)-;O-(TETRAHYDRO-2H-PYRAN-2-YL)HYDROXYLAMINE;O-(TETRAHYDRO-PYRAN-2-YL)-HYDROXYLAMINE;O-(2H-Tetrahydropyran-2-yl)hydroxylamine;O-tertrahydroxy-pyran-2-yl-hydroxylamine;2-(Aminooxy)tetrahydro-2H-pyran;O-(oxan-2-yl)hydroxylaMine;O-(Tetrahydropyran-2-yl)-hydroxylaMine, 95+%
• CAS NO: 6723-30-4
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• EINECS: 1308068-626-2
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrans;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 6723-30-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 81 °C20 mm Hg(lit.)
• Flash Point: 180 °F
• Appearance: White/Low Melting Solid
• Density: 1.1274 (rough estimate)
• Vapor Pressure: 0.204mmHg at 25°C
• Refractive Index: 1.4206 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.28±0.20(Predicted)
• CAS DataBase Reference: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(6723-30-4)
• EPA Substance Registry System: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(6723-30-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6723-30-4(Hazardous Substances Data)

Usage

Description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine, characterized by its white powder form. It is known for its potential applications in various fields, particularly in the treatment of fibrotic and inflammatory diseases, as well as in the synthesis of certain marine alkaloids.

Uses

1. Used in Pharmaceutical Applications:
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as a therapeutic agent for treating fibrotic and inflammatory diseases. Its application in this field is due to its potential to alleviate the symptoms and progression of these conditions.
2. Used in Chemical Synthesis:
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid, which has demonstrated significant inhibitory activity against mycothiol S-conjugate amidase. This application highlights its utility in the development of novel compounds with potential biological activities.
3. Used in DNA Analysis:
The coupling of O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine with alkaline gel electrophoresis has been reported to improve the process of detecting single-strand breaks (SSBs) in DNA. This application underscores its role in enhancing the accuracy and efficiency of DNA damage assessment techniques.

InChI:InChI=1/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

Downstream Products

• 76440-73-8 2-Hydroxy-3-phenyl-N-(tetrahydro-2H-2-pyranyloxy)propionamid 
• 75626-58-3 (Z)-4-<<(benzyloxy)carbonyl>amino>-α-<<(tetrahydro-2H-pyran-2-yl)oxy>imino>phenylacetic acid 
• 151824-92-9 3-Hydroxy-5-phenyl-N-(2-tetrahydropyranyloxy)thiophen-2-carboxamid 
• 112270-88-9 N-[(E)-3-(3-Phenoxy-phenyl)-allyl]-O-(tetrahydro-pyran-2-yl)-hydroxylamine 
• 154421-75-7 2-<3-(2,5-Dimethyl)thienyl>-α-hydroxy-3-phenyl-N-(tetrahydropyranyl-2-oxy)propanamid 
• 154421-77-9 2-<3-(5-Chlor-2-methyl)thienyl>-α-hydroxy-3-phenyl-N-(tetrahydropyranyl-2-oxy)propanamid 
• 112800-52-9 2-Hydroxy-3-phenyl-N-(tetrahydro-2H-2-pyranyloxy)-2-(2-thienyl)propanamid 
• 6584-61-8 O-(tetrahydro-2-pyranyl)benzohydroxamic acid 
• 76440-71-6 2-Hydroxy-N-(tetrahydro-2H-2-pyranyloxy)phenylacetamid 
• 76440-77-2 2-Hydroxy-2,2-diphenyl-N-(tetrahydro-2H-2-pyranyloxy)-acetamid 
• 131662-01-6 N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine 
• 285572-43-2 (2S,3R)-2-hydroxy-3-(phenylsulfanyl)heptanoic acid (tetrahydropyran-2-yloxy)amide 

Relevant articles and documents

Heterocyclic inhibitors of farnesyl protein transferase

Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein:, A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or substituted phenyl;, G1 is S or O;, G2 is H, -C(O)OH, -C(O)NH2, 5-tetrazolyl, -C(O)N(R7)OH or -CH2OH;, X is O or R8N;, Y and Z are each independently -CH2- or -C(O)-;, R1, R2, R3, R4, R5, R6 and R7 are each independently H or alkyl;, R1 may also be alkanoyl, R1 and A1 taken together may be -(CH2)m;, R8 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or -C(O)R9;, R9 is H, alkyl, phenyl, phenylalkyl, substituted phenyl or (substituted phenyl)alkyl;, m is 3 or 4;, n is 0, 1 or 2;, p is 0, 1 or 2; and, q is 0 or 1, with the proviso that when p is 0, then q is also 0.