67230-92-6Relevant articles and documents
Reaction of halothane with carbonyl compounds in the presence of bases
Ando, Akira,Takahashi, Junko,Nakamura, Yuki,Maruyama, Naoki,Nishihara, Masakazu,Fukushima, Kaori,Moronaga, Jin,Inoue, Mayumi,Sato, Kazuyuki,Omote, Masaaki,Kumadaki, Itsumaro
, p. 283 - 285 (2007/10/03)
The reaction of halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with aldehydes and ketones in the presence of bases was found to give 1-alkyl- or 1-aryl-2-bromo-2-chloro-3,3, 3-trifluoropropanols (2) or 2-chloro-3,3-difluoro-2-propenols (3) selecti
Synthesis of fluorine compounds using zinc complex of halothane
Takagi, Toshiyuki,Nakamoto, Makoto,Sato, Kazuyuki,Koyama, Mayumi,Ando, Akira,Kumadaki, Itsumaro
, p. 12667 - 12676 (2007/10/03)
We have reported the Grignard reaction of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with ketones gave unexpected products, α-(1-bromo-1-chloro-2,2,2-trifluoroethyl)alcohols (4) at a low temperature. However, this reaction hardly proceeded with aldehydes. Now, we found the reaction of 1 with aldehydes in the presence of zinc gave not only products of type 4, but α-(1-chloro-2,2,2-trifluoroethyl)alcohols (3), the expected type of products, under mild conditions in good to moderate yields.
Synthetic utility of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane): the reaction between HCFC-123 and aldehydes using zinc
Tamura, Masanori,Sekiya, Akira
, p. 119 - 122 (2007/10/02)
HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) reacted with zinc and aldehydes to afford predominantly either 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols or 1-substituted 2,2-dichloro-3,3,3-trifluoro-1-propanols.The reactions proceeded via 1,1-dichloro-2,2,2-trifluoroethylzinc chloride as an organozinc intermediate. - Keywords: 2,2-Dichloro-1,1,1-trifluoroethane; Reaction; Aldehydes; Zinc; 1,1-Dichloro-2,2,2-trifluoroethylzinc chloride
