67287-36-9 Usage
Description
2-(2-Chloro-3,4-dimethoxyphenyl)ethanamine is an organic compound that serves as a key reactant in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a chloro and two methoxy groups attached to a phenyl ring, with an ethanamine group connected to the 2-position. This unique structure endows it with specific chemical properties that make it valuable in the development of pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
2-(2-Chloro-3,4-dimethoxyphenyl)ethanamine is used as a reactant for the preparation of 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols. These compounds are potent D-1 dopamine agonists, which have potential applications in the treatment of various neurological and psychiatric disorders, such as Parkinson's disease and schizophrenia. The presence of the chloro and methoxy groups in 2-(2-chloro-3,4-dimethoxyphenyl)ethanamine contributes to the desired pharmacological properties of the resulting benzazepine derivatives, enhancing their efficacy as D-1 dopamine agonists.
Check Digit Verification of cas no
The CAS Registry Mumber 67287-36-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,2,8 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67287-36:
(7*6)+(6*7)+(5*2)+(4*8)+(3*7)+(2*3)+(1*6)=159
159 % 10 = 9
So 67287-36-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H14ClNO2/c1-13-8-4-3-7(5-6-12)9(11)10(8)14-2/h3-4H,5-6,12H2,1-2H3
67287-36-9Relevant articles and documents
Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues
Maresh, Justin J.,Ralko, Arthur A.,Speltz, Tom E.,Burke, James L.,Murphy, Casey M.,Gaskell, Zachary,Girel, Joann K.,Terranova, Erin,Richtscheidt, Conrad,Krzeszowiec, Mark
, p. 2891 - 2894 (2015/02/02)
A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.
Process for the preparation of Fenoldopam Mesylate
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Page/Page column 6, (2008/06/13)
Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.
Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: Halogen and methyl analogues of fenoldopam
Weinstock,Ladd,Wilson,Brush,Yim,Gallagher Jr.,McCarthy,Silvestri,Sarau,Flaim
, p. 2315 - 2325 (2007/10/02)
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