67326-20-9

Basic information

• Product Name: Benzoic acid, 3-(chlorocarbonyl)-, ethyl ester
• CAS NO: 67326-20-9
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Mol File: 67326-20-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-(chlorocarbonyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-(chlorocarbonyl)-, ethyl ester(67326-20-9)
• EPA Substance Registry System: Benzoic acid, 3-(chlorocarbonyl)-, ethyl ester(67326-20-9)

Safety Data

• Hazardous Substances Data: 67326-20-9(Hazardous Substances Data)

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 141-75-3 butyryl chloride 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 121-91-5 isophthalic acid 
• 64-17-5 ethanol 
• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 18189-42-9 4-carboxybenzoic acid ethyl ester 

Downstream Products

• 18189-42-9 4-carboxybenzoic acid ethyl ester 
• 2425-96-9 diethyl 3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoate 
• 4416-76-6 3,3'-[1,3,4]oxadiazole-2,5-diyl-bis-benzoyl chloride 
• 2425-93-6 3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoic acid 
• 117424-82-5 ethyl 2-<6-(phenylhexyl)oxy>-5-<3-(ethoxycarbonyl)benzoyl>benzenepropanoate 
• 117423-81-1 ethyl 5-(3-carbethoxybenzoyl)-2-(decyloxy)benzenepropanoate 
• 117423-74-2 LY223982 
• 128578-11-0 3-{3-(2-Carboxy-ethyl)-4-[(Z)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-benzoyl}-benzoic acid 
• 117424-97-2 5-(3-carboxybenzoyl)-2-<(6-phenylhexyl)oxy>benzenepropanoic acid 
• 117423-95-7 5-(3-carboxybenzoyl)-2-(decyloxy)benzenepropanoic acid 
• 128578-16-5 5-[[3-(ethoxycarbonyl)phenyl]carbonyl]-2-hydroxybenzenepropanoic acid ethyl ester 
• 117424-80-3 5-(3-carboxybenzoyl)-2-hydroxybenzenepropanoic acid 
• 128577-86-6 3-[4-[(E)-6-(2,4-Dimethoxy-phenyl)-hex-5-enyloxy]-3-(2-ethoxycarbonyl-ethyl)-benzoyl]-benzoic acid ethyl ester 
• 128577-91-3 3-{3-(2-Ethoxycarbonyl-ethyl)-4-[(E)-6-(4-methanesulfonyloxy-phenyl)-hex-5-enyloxy]-benzoyl}-benzoic acid ethyl ester 

Relevant articles and documents

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.

One-pot synthetic method for m-acetylbenzoic acid

The invention relates to a synthetic method, in particular to a one-pot synthetic method for m-acetylbenzoic acid. According to the one-pot synthetic method for the m-acetylbenzoic acid, there is no need to purify an intermediate product. The reaction equation of the m-acetylbenzoic acid is shown in the description, wherein R refers to methyl or ethyl, and R1 refers to methyl or ethyl or n-propyl. Compared with synthetic methods in the prior art, the synthetic method has the advantages that raw materials are low in price and easy to get, reaction conditions are mild, the obtained intermediate product can be directly used for a reaction in a next step without being separated and purified, and therefore process cost is greatly lowered.