67341-03-1

Basic information

• Product Name: 12-(T-BOC-AMINO)-1-DODECANOL
• Synonyms: 12-(T-BOC-AMINO)-1-DODECANOL;(12-Hydroxydodecyl)carbaMic Acid 1,1-DiMethylethyl Ester;N-(12-Hydroxydodecyl)carbaMic Acid 1,1-DiMethylethyl Ester;N-Boc-12-aminododecan-1-ol
• CAS NO: 67341-03-1
• Molecular Formula: C₁₇H₃₅NO₃
• Molecular Weight: 301.46
• Product Categories: All Aliphatics;Aliphatics
• Mol File: 67341-03-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 415.5°C at 760 mmHg
• Flash Point: 205.1°C
• Appearance: /
• Density: 0.945g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.461
• Storage Temp.: -20°C Freezer
• PKA: 12.94±0.46(Predicted)
• CAS DataBase Reference: 12-(T-BOC-AMINO)-1-DODECANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 12-(T-BOC-AMINO)-1-DODECANOL(67341-03-1)
• EPA Substance Registry System: 12-(T-BOC-AMINO)-1-DODECANOL(67341-03-1)

Safety Data

• Hazardous Substances Data: 67341-03-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C17H35NO3/c1-17(2,3)21-16(20)18-14-12-10-8-6-4-5-7-9-11-13-15-19/h19H,4-15H2,1-3H3,(H,18,20)

Upstream product

• 67107-87-3 12-aminododecan-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1031684-74-8 12-(N-tert-butoxycarbonyl)aminododecanoic acid methyl ester 
• 18934-81-1 N-(tert-butyloxycarbonyl)-12-aminododecanoic acid 
• 693-57-2 12-Aminododecanoic acid 
• 53005-24-6 methyl 12-aminododecanoate 
• 1611-56-9 1-Bromo-11-hydroxyundecane 
• 73782-16-8 12-hydroxydodecanoic nitrile 
• 207453-54-1 12-amino-1-dodecanol chlorohydrate 

Downstream Products

• 906072-85-3 12-(tert-butylcarbamoyl)dodecyl-4-nitrophenyl-2,2-diphenylethyl phosphate 
• 906072-80-8 bis-N,N-(p-nitrophenyl-2,2-diphenylethyl-12-aminododecyl phosphate)fumaramide 
• 906072-82-0 bis-N,N-(p-nitrophenyl-2,2-diphenylethyl-12-aminododecyl phosphate)-2,5-dimethoxyterephthalamide 
• 154371-98-9 (12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders

Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a therapeutic target for anti-prostate cancer agents, and recently we identified triazole 1 as an inhibitor of KDM5C. Compound 1 exhibited highly potent KDM5C-inhibitory activity in in vitro enzyme assays, but did not show strong anticancer effects. Therefore, a different approach is needed for the development of anticancer agents targeting KDM5C. Here, we attempted to identify KDM5C degraders by focusing on a protein-knockdown strategy. Compound 3 b, which was designed based on compound 1, degraded KDM5C and inhibited the growth of prostate cancer PC-3 cells more strongly than compound 1. These findings suggest that KDM5C degraders are more effective as anticancer agents than compounds that only inhibit the catalytic activity of KDM5C.

Graphene Oxide Cellular Delivery of Hydrophilic Small Molecules

Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.

Functionalised nanoparticles, their production and use

Stable complexes are described, formed by mono- and di-functional compounds bound to nanoparticles composed of various types of transition metal oxides and of metals useful in the production processes of different types of new materials (such as for examp