67346-59-2

Basic information

• Product Name: Benzeneethanamine, 4-methoxy-a-methyl-N-(phenylmethyl)-, (S)-
• CAS NO: 67346-59-2
• Molecular Formula: C17H21NO
• Molecular Weight: 255.36
• Mol File: 67346-59-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzeneethanamine, 4-methoxy-a-methyl-N-(phenylmethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, 4-methoxy-a-methyl-N-(phenylmethyl)-, (S)-(67346-59-2)
• EPA Substance Registry System: Benzeneethanamine, 4-methoxy-a-methyl-N-(phenylmethyl)-, (S)-(67346-59-2)

Safety Data

• Hazardous Substances Data: 67346-59-2(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 100-46-9 benzylamine 
• 1096141-37-5 C₁₇H₁₉NO 
• 43229-65-8 [2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amine 
• 188690-85-9 C₈H₈O₃*C₁₇H₂₁NO 
• 64-13-1 2-amino-1-(4-methyoxyphenyl)propane 
• 100-52-7 benzaldehyde 

Downstream Products

• 67346-49-0 (S,S)-formoterol 
• 67346-51-4 N-(2-Hydroxy-5-{(R)-1-hydroxy-2-[(S)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide 

Relevant articles and documents

Enantio- and diastereoselective synthesis of all four stereoisomers of formoterol

Enantioselective syntheses of all four stereoisomers of formoterol are accomplished using asymmetric catalytic borane reductions with chiral oxazaborolidines as reducing agents.

Direct Asymmetric Reductive Amination for the Synthesis of Chiral β-Arylamines

The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure β-arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20 000) and enantioselectivity (up to 99 % ee). Additives played important roles in this reductive coupling reaction. Asymmetric reductive coupling of a ketone and an amine is a straightforward and atom-economic approach for preparing optically enriched amines. The highly efficient and direct asymmetric reductive amination of arylacetones, catalyzed by an iridium complex, supplies enantiomerically pure β-arylamines. The new phosphoramidite ligands reported show superb reactivity and enantioselectivity in this reductive coupling. M.S.=molecular sieves, TFA=trifluoroacetic acid.

Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

This disclosure concerns the discovery of the use of fenoterol and (R,R)- and (R,S)-fenoterol analogs for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analog or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.