67363-82-0

Basic information

• Product Name: N-(4-methylphenyl)-2-naphthamide
• Synonyms: N-(4-methylphenyl)-2-naphthamide
• CAS NO: 67363-82-0
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.3178
• Mol File: 67363-82-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)-2-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-2-naphthamide(67363-82-0)
• EPA Substance Registry System: N-(4-methylphenyl)-2-naphthamide(67363-82-0)

Safety Data

• Hazardous Substances Data: 67363-82-0(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 2243-83-6 2-naphthaloyl chloride 
• 580-13-2 2-bromonaphthalene 
• 622-58-2 p-Tolylisocyanate 
• 613-46-7 2-naphthalenecarbonitrile 
• 532-02-5 2-naphthalenesulfonic acid sodium salt 
• 93-09-4 naphthalene-2-carboxylate 
• 14289-45-3 2-(naphthalen-2-yl)-2-oxoacetic acid 
• 93-08-3 methyl 2-naphthyl ketone 

Relevant articles and documents

Silver-promoted decarboxylative amidation of α-keto acids with amines

A general and effective method for the synthesis of amides through decarboxylative amidation of α-keto acids with amines has been developed. The reaction proceeded smoothly to afford the corresponding amide products in good yield under air and shows excellent functional group tolerance. In addition, the protocol can be further applied in the synthesis of heterocyclic compounds like benzimidazoles.

Visible-light-mediated decarboxylation/oxidative amidation of α-keto acids with amines under mild reaction conditions using O2

Photochemistry has ushered in a new era in the development of chemistry, and photoredox catalysis has become a hot topic, especially over the last five years, with the combination of visible-light photoredox catalysis and radical reactions. A novel, simple, and efficient radical oxidative decarboxylative coupling with the assistant of the photocatalyst [Ru(phen)3]Cl 2 is described. Various functional groups are well-tolerated in this reaction and thus provides a new approach to developing advanced methods for aerobic oxidative decarboxylation. The preliminary mechanistic studies revealed that: 1)an SET process between [Ru(phen)3]2+* and aniline play an important role; 2)O2 activation might be the rate-determining step; and 3)the decarboxylation step is an irreversible and fast process. Bring to light: A new approach to oxidative decarboxylation under visible light using O2 as the oxidant has been developed. A variety of functional groups were well-tolerated in this reaction and insights into the mechanism were investigated with the assistance of EPR spectroscopy, cyclic voltammetry, and theoretical studies.

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.