67388-67-4Relevant articles and documents
SYNTHESIS OF 1-HYDROXY-2-(N-SUBSTITUTED)AZATWISTANES
Kadzyauskas, P. P.,Malinauskene, Yu. A.,Butkus, E. P.,Zefirov, N. S.
, p. 727 - 729 (1980)
The reductive amination of bicyclononane-2,6-dione with benzylamine or isopropylamine in the presence of sodium borohydride proceeds with the formation of 1-hydroxy-2-(N-substituted)azatwistanes.When 1-hydroxy-2-benzyl-2-azatwistane is refluxed with acetic anhydride, the ring is opened to give 2-acetoxy-6-acetylbenzylaminobicyclononane.The structures of the synthesized compounds were proved by means of the IR and PMR spectra and the results of elementary analysis.