67469-45-8

Basic information

• Product Name: Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride
• CAS NO: 67469-45-8
• Molecular Formula: C28H30F2N2O.2ClH
• Molecular Weight: 521.478
• Mol File: 67469-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride(67469-45-8)
• EPA Substance Registry System: Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride(67469-45-8)

Safety Data

• Hazardous Substances Data: 67469-45-8(Hazardous Substances Data)

Upstream product

• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 18903-01-0 trans-1-cinnamylpiperazine 
• 50366-31-9 2-[bis(4-fluorophenyl)methoxy]ethyl chloride 

Relevant articles and documents

Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake

Substituted 1-[2-(diphenylmethoxy)ethyl]piperazines were synthesized and tested for inhibitory activity on dopamine uptake by synaptosomal preparations of rat corpus striatum. Especially 4-(3-phenyl-2-propenyl)substitution yielded very potent inhibitors with IC50 values of about 1 to 2 nM, activities that surpass that of benztropine 100 times. Compared with other monoamine uptake processes, the effect on dopamine uptake was highly specific. QSAR-analysis showed that substituents in the diphenylmethoxy group combining a strong inductive effect with a small volume provided optimal potency. In contrast, for those in the solitary phenyl group a combination of strong electron-withdrawing effect and a small volume was required.