67469-57-2

Basic information

• Product Name: 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
• Synonyms: Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-;1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE;GBR 12783 DIHYDROCHLORIDE;GBR127832HCl;GBR 12921;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine;GBR-12783;1-[2-(diphenylMethoxy)ethyl]-4-(3-phenylprop-2-en-1-yl)piperazine dihydrochloride
• CAS NO: 67469-57-2
• Molecular Formula: C28H34Cl2N2O
• Molecular Weight: 485.49
• Product Categories: Dopamine receptor
• Mol File: 67469-57-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 551℃
• Flash Point: 148℃
• Appearance: /
• Density: 1.085
• Vapor Pressure: 3.63E-12mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Desiccate at -20°C
• Solubility: Methanol (Slightly), Water (Slightly, Heated)
• CAS DataBase Reference: 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE(67469-57-2)
• EPA Substance Registry System: 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE(67469-57-2)

Safety Data

• Hazardous Substances Data: 67469-57-2(Hazardous Substances Data)

Usage

Description

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE is a chemical compound with a complex structure, characterized by its white to off-white powder appearance. It is a potent and selective inhibitor of dopamine uptake, which makes it a significant compound in the field of pharmaceuticals and neuroscience.

Uses

Used in Pharmaceutical Industry:
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE is used as a potent and selective inhibitor for dopamine uptake. Its application in this industry is due to its ability to modulate dopamine levels, which can be beneficial in the treatment of various neurological and psychiatric disorders associated with dopamine dysregulation.
Used in Research and Development:
In the field of research and development, 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE serves as a valuable tool for studying the role of dopamine in the brain. Its selective inhibition of dopamine uptake can help researchers better understand the mechanisms underlying dopamine-related conditions and develop more targeted and effective treatments.
Used in Drug Delivery Systems:
Similar to gallotannin, 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE may also benefit from novel drug delivery systems to enhance its applications and efficacy. By employing various organic and metallic nanoparticles as carriers, its delivery, bioavailability, and therapeutic outcomes can be improved, potentially leading to more effective treatments for conditions related to dopamine dysregulation.

Biological Activity

A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

InChI:InChI=1/C28H32N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-17,28H,18-24H2/b13-10+