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67469-75-4

67469-75-4

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67469-75-4 Usage

Uses

GBR 12783 Dihydrochloride is a potent, selective dopamine uptake inhibitor.

Check Digit Verification of cas no

The CAS Registry Mumber 67469-75-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,4,6 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 67469-75:
(7*6)+(6*7)+(5*4)+(4*6)+(3*9)+(2*7)+(1*5)=174
174 % 10 = 4
So 67469-75-4 is a valid CAS Registry Number.

67469-75-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piper azine dihydrochloride

1.2 Other means of identification

Product number -
Other names 2,9,10(1H)-Anthracenetrione,6-ethyl-4,5-dihydroxy-1,1,3,7-tetramethyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67469-75-4 SDS

67469-75-4Downstream Products

67469-75-4Relevant articles and documents

Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake

Van Der Zee,Koger,Gootjes,Hespe

, p. 363 - 370 (2007/10/02)

Substituted 1-[2-(diphenylmethoxy)ethyl]piperazines were synthesized and tested for inhibitory activity on dopamine uptake by synaptosomal preparations of rat corpus striatum. Especially 4-(3-phenyl-2-propenyl)substitution yielded very potent inhibitors with IC50 values of about 1 to 2 nM, activities that surpass that of benztropine 100 times. Compared with other monoamine uptake processes, the effect on dopamine uptake was highly specific. QSAR-analysis showed that substituents in the diphenylmethoxy group combining a strong inductive effect with a small volume provided optimal potency. In contrast, for those in the solitary phenyl group a combination of strong electron-withdrawing effect and a small volume was required.

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