675589-40-9

Basic information

• Product Name: (3R,7aS)-3-phenyl-7a-(2-phenylethyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one
• Synonyms: (3R,7aS)-3-phenyl-7a-(2-phenylethyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one
• CAS NO: 675589-40-9
• Molecular Weight: 307.392
• Mol File: 675589-40-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R,7aS)-3-phenyl-7a-(2-phenylethyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,7aS)-3-phenyl-7a-(2-phenylethyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one(675589-40-9)
• EPA Substance Registry System: (3R,7aS)-3-phenyl-7a-(2-phenylethyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one(675589-40-9)

Safety Data

• Hazardous Substances Data: 675589-40-9(Hazardous Substances Data)

Upstream product

• 90147-73-2 ethyl 4-oxo-6-phenylhexanoate 
• 56613-80-0 D-2-phenylglycinol 
• 3277-89-2 phenethylmagnesium bromide 

Relevant articles and documents

Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2′-pyrrolidine] Backbone

P,Nsp3-bidentate chiral ligands bearing spiro[indane-1,2′-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97percent ee and 99percent yield. A crystal structure of [Pd(II)(η3-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C2-symmetric bisphosphine, P,Nsp2-bidentate, and P,Nsp3-bidentate ligands in tested allylic substitutions. ?

Asymmetric synthesis of spiro 2-pyrrolidin-5-ones, 2-piperidin-6-ones and 1-isoindolin-3-ones. Part 1: N-acyliminium ion cyclisations with an internal arene nucleophile

A series of chiral non-racemic 5,5- and 5,6-bicyclic lactams is prepared from (R)-phenylglycinol. These are isomerised on treatment with aluminium trichloride in 1,2-dichloroethane to give spiro lactams in high yield and >3:1 diastereoselectivity. From four structures determined by X-ray crystallography, it follows that spiro indenes are formed preferentially with retention of configuration at the spiro carbon atom and spiro naphthalenes with inversion.